Academic Journal
Peripheral immunosenescence and central neuroinflammation: A dangerous liaison - A dietary approach
| العنوان: | Peripheral immunosenescence and central neuroinflammation: A dangerous liaison - A dietary approach |
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| المؤلفون: | Magrone T., Magrone M., Russo M. A., Jirillo E. |
| المساهمون: | Magrone, T., Magrone, M., Russo, M. A., Jirillo, E. |
| سنة النشر: | 2020 |
| المجموعة: | Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| مصطلحات موضوعية: | Ageing, Cellular and molecular rehabilitation, Immunity, Inflamm-ageing, Neuroinflammation, Nutraceuticals |
| الوصف: | Background & Objectives: In old people, both innate and adaptive immune responses are impaired, thus leading to a condition of systemic inflamm-ageing, even including the involvement of the central nervous system (CNS). Aims: Here, main mechanisms of the immune ageing and neuro-inflammation will be discussed along with the dietary approaches for the modulation of age related diseases. Discussion: Neuroinflammation is caused by the passage of inflammatory mediators through the brain blood barrier to CNS. Then, in the brain, antigenic stimulation of microglia and/or its activation by peripheral cytokines lead to a robust production of free radicals with another wave of pro-inflammatory cytokines which, in turn, causes massive neuronal damage. Also, infiltrating T cells [T helper (h) and T cytotoxic cells] contribute to neuronal damage. Additionally, a peripheral imbalance between inflammatory Th17 cells and anti-inflammatory T regulatory cells seems to be prevalent in the aged brain, thus leading to a proinflammatory profile. Alzheimer’s disease, Parkinson’s disease and multiple sclerosis will be described as typical neurodegenerative diseases. Finally, modulation of the immune response thanks to the anti-oxidant and anti-inflammatory effects exerted by dietary products and nutraceuticals in ageing will be discussed. Special emphasis will be placed on polyunsaturated fatty acids, polyphenols, micronutrients and pre-probiotics and synbiotics. Conclusion: Ageing is characterized by an imbalance subversion of the immune system with a condition of inflamm-ageing. Neuroinflammation and neurodegenerative diseases seem to be a central mani-festation of a peripheral perturbation of the immune machinery. Dietary products and nutraceuticals may lead to a down-regulation of the oxidative and pro-inflammatory profile in ageing. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32250234; info:eu-repo/semantics/altIdentifier/wos/WOS:000587329600005; volume:20; issue:9; firstpage:1391; lastpage:1411; numberofpages:21; journal:ENDOCRINE, METABOLIC & IMMUNE DISORDERS DRUG TARGETS; http://hdl.handle.net/11586/319844; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85086649040; https://pubmed.ncbi.nlm.nih.gov/32250234/ |
| DOI: | 10.2174/1871530320666200406123734 |
| الاتاحة: | http://hdl.handle.net/11586/319844 https://doi.org/10.2174/1871530320666200406123734 https://pubmed.ncbi.nlm.nih.gov/32250234/ |
| رقم الانضمام: | edsbas.25CCD173 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1871530320666200406123734 |
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