Academic Journal
Ex Vivo Antiplatelet Effects of Oral Anticoagulants
| العنوان: | Ex Vivo Antiplatelet Effects of Oral Anticoagulants |
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| المؤلفون: | Renda, Giulia, Bucciarelli, Valentina, Barbieri, Giulia, Lanuti, Paola, Berteotti, Martina, Malatesta, Gelsomina, Cesari, Francesca, Salvatore, Tanya, Giusti, Betti, Gori, Anna Maria, Marcucci, Rossella, De Caterina, Raffaele |
| المساهمون: | Renda, Giulia, Bucciarelli, Valentina, Barbieri, Giulia, Lanuti, Paola, Berteotti, Martina, Malatesta, Gelsomina, Cesari, Francesca, Salvatore, Tanya, Giusti, Betti, Gori, Anna Maria, Marcucci, Rossella, De Caterina, Raffaele |
| سنة النشر: | 2024 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | DOAC, NOAC, antiplatelet effect, direct oral anticoagulant, non-vitamin K antagonist oral anticoagulant, oral anticoagulant, platelets |
| الوصف: | Background: The impact of non-vitamin K antagonist oral anticoagulants (NOACs) on platelet function is still unclear. We conducted a comprehensive ex vivo study aimed at assessing the effect of the four currently marketed NOACs on platelet function. Methods: We incubated blood samples from healthy donors with concentrations of NOACs (50, 150 and 250 ng/mL), in the range of those achieved in the plasma of patients during therapy. We evaluated generation of thrombin; light transmittance platelet aggregation (LTA) in response to adenosine diphosphate (ADP), thrombin receptor-activating peptide (TRAP), human gamma-thrombin (THR) and tissue factor (TF); generation of thromboxane (TX)B2; and expression of protease-activated receptor (PAR)-1 and P-selectin on the platelet surface. Results: All NOACs concentration-dependently reduced thrombin generation compared with control. THR-induced LTA was suppressed by the addition of dabigatran at any concentration, while TF-induced LTA was reduced by factor-Xa inhibitors. ADP- and TRAP-induced LTA was not modified by NOACs. TXB2 generation was reduced by all NOACs, particularly at the highest concentrations. We found a concentration-dependent increase in PAR-1 expression after incubation with dabigatran, mainly at the highest concentrations, but not with FXa inhibitors; P-selectin expression was not changed by any drugs. Conclusions: Treatment with the NOACs is associated with measurable ex vivo changes in platelet function, arguing for antiplatelet effects beyond the well-known anticoagulant activities of these drugs. There are differences, however, among the NOACs, especially between dabigatran and the FXa inhibitors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38667729; info:eu-repo/semantics/altIdentifier/wos/WOS:001210426900001; volume:11; issue:4; numberofpages:13; journal:JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE; https://hdl.handle.net/11564/830273; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85191692234; https://www.mdpi.com/2308-3425/11/4/111 |
| DOI: | 10.3390/jcdd11040111 |
| الاتاحة: | https://hdl.handle.net/11564/830273 https://doi.org/10.3390/jcdd11040111 https://www.mdpi.com/2308-3425/11/4/111 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.257B8FF1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jcdd11040111 |
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