Academic Journal
Short-echo-time magnitude image derived from quantitative susceptibility mapping could resemble neuromelanin-sensitive MRI image in substantia nigra
| العنوان: | Short-echo-time magnitude image derived from quantitative susceptibility mapping could resemble neuromelanin-sensitive MRI image in substantia nigra |
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| المؤلفون: | Liu, Xue Ling, Yang, Li Qin, Liu, Feng Tao, Wu, Pu-Yeh, Zhang, Yong, Zhuang, Han, Shi, Yong Hong, Wang, Jian, Geng, Dao Ying, Li, Yu Xin |
| المساهمون: | Science and Technology Commission of Shanghai Municipality, National Natural Science Foundation of China, Ministry of Science and Technology of the People’s Republic of China, Huashan Hospital Fudan University Scientific Research project |
| المصدر: | BMC Neurology ; volume 20, issue 1 ; ISSN 1471-2377 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2020 |
| الوصف: | Background In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility mapping (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantitatively comparing the spatial similarity and diagnosis performances for Parkinson’s disease (PD). Methods QSM and NM-MRI were performed in 18 PD patients and 15 healthy controls (HCs). The setMag images were calculated using the short-echo-time magnitude images. Bilateral hyperintensity areas of SN (SN hyper ) were manually segmented on setMag and NM-MRI images by two raters in a blinded manner. The inter-rater reliability was evaluated by the intraclass correlation coefficients (ICC) and the Dice similarity coefficient (DSC). Then the inter-modality (i.e. setMag and NM-MRI) spatial similarity was quantitatively assessed using DSC and volume of the consensual voxels identified by both of two raters. The performances of mean SN hyper volume for PD diagnosis on setMag and NM-MRI images were evaluated using receiver operating characteristic (ROC) analysis. Results The SN hyper segmented by two raters showed substantial to excellent inter-rater reliability for both setMag and NM-MRI images. The DSCs of SN hyper between setMag and NM-MRI images showed substantial to excellent voxel-wise overlap in HCs (0.80 ~ 0.83) and PD (0.73 ~ 0.76), and no significant difference was found between the SN hyper volumes of setMag and NM-MRI images in either HCs or PD (p > 0.05). The mean SN hyper volume was significantly decreased in PD patients in comparison with HCs on both setMag images (77.61 mm 3 vs 95.99 mm 3 , p < 0.0001) and NM-MRI images (79.06 mm 3 vs 96.00 mm 3 , p < 0.0001). Areas under the curve (AUCs) of mean SN hyper volume for PD diagnosis were 0.904 on setMag and 0.906 on NM-MRI images. No significant difference was found between the two curves ( p = 0.96). Conclusions SN hyper on setMag derived from QSM demonstrated substantial spatial overlap with that on NM-MRI and provided ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12883-020-01828-8 |
| DOI: | 10.1186/s12883-020-01828-8.pdf |
| DOI: | 10.1186/s12883-020-01828-8/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12883-020-01828-8 https://link.springer.com/content/pdf/10.1186/s12883-020-01828-8.pdf https://link.springer.com/article/10.1186/s12883-020-01828-8/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.2561BDCF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12883-020-01828-8 |
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