Academic Journal
Selecting goats for juniper consumption did not improve their liver Phase I detoxification
| العنوان: | Selecting goats for juniper consumption did not improve their liver Phase I detoxification |
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| المؤلفون: | Walker, John W, Shoemake, Brian M, Quadros, Danilo G, Thorne, Jacob W, Cahill, Noah C |
| المساهمون: | National Institute of Food and Agriculture, Texas A&M University, College of Veterinary Medicine |
| المصدر: | Journal of Animal Science ; volume 101 ; ISSN 0021-8812 1525-3163 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | A sodium pentobarbital-induced sleep time study was conducted on 15 adult intact male Boer × Spanish goats selected for high (J+, n = 7) or low (J−, n = 8) juniper consumption (estimated breeding values of 13.1 ± 1.0 and −14.3 ± 0.8, respectively; mean ± standard deviation). Pentobarbital sleep time is an in vivo assay of Phase I hepatic metabolism that can be induced by exposure to barbiturates and monoterpenes. Monoterpenes and pentobarbital are initially oxidized by this pathway; thus, we hypothesized that J+ goats would have shorter sleep times than J− goats. Time to the righting reflex after pentobarbital-induced sleep was measured in all goats following a minimum period of 21 d on three different diets: 1) grazing juniper-infested rangeland (JIR), 2) forage diet with no monoterpenes (M0), and 3) forage diet with 8 g/kg added monoterpenes from camphor, sabinene, and α-pinene in a w/w ratio of 5:4:1 (M+). Fecal samples from the JIR diet were analyzed with near-infrared spectroscopy for the percentage of juniper in the diet. Fecal samples from the JIR and M+ diets were analyzed for camphor and sabinene concentrations. The percentage of juniper in the diet of J+ goats grazing rangelands was greater (P = 0.001) than J− goats (31.1% and 18.6%, respectively). Sleep time did not differ between selection lines (P = 0.36). However, the sleep time of the goats fed M+ diet was 26 min shorter (P < 0.001) than JIR or M0 diets, which were equal. The concentration of camphor and sabinene in the feces was higher (P < 0.001) for goats on the M+ diet than on the JIR diet. There were no differences between selection lines in the serum enzymes indicative of liver disease (aspartate aminotransferase, bilirubin, gamma-glutamyl transferase, and glutamate dehydrogenase; P > 0.12), and all treatment means were within the reference interval. Selecting goats for juniper consumption did not affect the Phase I detoxification system, and several alternative hypotheses for differences in juniper consumption ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/jas/skad180 |
| DOI: | 10.1093/jas/skad180/50632363/skad180.pdf |
| DOI: | 10.1093/jas/skad180/50855191/skad180.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/jas/skad180 https://academic.oup.com/jas/advance-article-pdf/doi/10.1093/jas/skad180/50632363/skad180.pdf https://academic.oup.com/jas/article-pdf/doi/10.1093/jas/skad180/50855191/skad180.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.255108E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jas/skad180 |
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