Academic Journal
BDNF Val66Met polymorphism and peripheral protein levels in pediatric bipolar disorder and attention‐deficit/hyperactivity disorder
| العنوان: | BDNF Val66Met polymorphism and peripheral protein levels in pediatric bipolar disorder and attention‐deficit/hyperactivity disorder |
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| المؤلفون: | Zeni, C. P., Tramontina, S., Aguiar, B. W., Salatino‐Oliveira, A., Pheula, G. F., Sharma, A., Stertz, L., Moreira Maia, C. R., Hutz, M., Kapczinski, F. P., Rohde, L. A. |
| المساهمون: | Fundação Instituto de Pesquisas Econômicas, Hospital de Clínicas de Porto Alegre, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Novartis, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Stanley Medical Research Institute, Eli Lilly and Company, AstraZeneca, Roche, Bristol-Myers Squibb, Shire |
| المصدر: | Acta Psychiatrica Scandinavica ; volume 134, issue 3, page 268-274 ; ISSN 0001-690X 1600-0447 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2016 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objective Frontiers between pediatric bipolar disorder (PBD) and attention‐deficit/hyperactivity disorder (ADHD) are not well defined. Few studies have addressed potentially different neurobiological factors between the two disorders. Brain‐derived neurotrophic factor (BDNF) has been increasingly recognized for its etiologic and prognostic role in adult bipolar disorder (BD) studies. This study aimed to examine the BDNF gene polymorphism and potential alterations in BDNF serum levels in the pediatric ADHD patients with or without comorbid BD illness. Method We assessed the non‐synonymous single‐nucleotide polymorphism in the BDNF gene (rs6265/Val66Met) and its serum levels in children and adolescents with BD comorbid with ADHD (BD + ADHD) and ADHD alone. Children and adolescents were assessed for psychiatric diagnoses using the Kiddie‐Sads‐Present and Lifetime Version (K‐SADS‐PL). Results Using Analysis of covariance ( ancova ) we detected a significant group effect (patients with BD + ADHD had higher serum levels than those with ADHD – F 80,3 = 8.73, P = 0.005). Conclusion Although the Val66Met polymorphism at the BDNF gene does not seem to play a significant role in children and adolescents with BD or ADHD, BDNF serum levels deserve further attention in future research on neurobiological aspects of BD and ADHD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/acps.12587 |
| الاتاحة: | http://dx.doi.org/10.1111/acps.12587 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Facps.12587 https://onlinelibrary.wiley.com/doi/pdf/10.1111/acps.12587 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.24E84750 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/acps.12587 |
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