Academic Journal
Recurrent Nonstatus Generalized Seizures Alter the Developing Chicken Brain
| العنوان: | Recurrent Nonstatus Generalized Seizures Alter the Developing Chicken Brain |
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| المؤلفون: | Gong, Zhao, Obenaus, André, Li, Nan, Sarty, Gordon E., Kendall, Edward J. |
| المصدر: | Epilepsia ; volume 44, issue 11, page 1380-1387 ; ISSN 0013-9580 1528-1167 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2003 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary: Purpose: Noninvasive magnetic resonance imaging was used to assess the evolution of seizure‐induced pathology in epileptic, carrier, and normal chickens. Our objective was to determine whether repetitively evoked seizures in an epileptic fowl model of generalized seizures resulted in altered brain development. Methods: Data were obtained from seizure and control groups at 45, 90, and 180 days after hatching. Results: At 180 days, apparent diffusion coefficient (ADC) values in the optic tectum and archistriatum of the stimulated epileptic chicks were reduced, whereas ADC values in the nonstimulated group remained unchanged. The mean brain volume of epileptic chickens from the stimulated group was smaller than that from the nonstimulated group at 90 and 180 days. Conclusions: These findings establish that recurrent seizures modify the brain matrix. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1046/j.1528-1157.2003.55902.x |
| الاتاحة: | http://dx.doi.org/10.1046/j.1528-1157.2003.55902.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1528-1157.2003.55902.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1528-1157.2003.55902.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.24CE015D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1046/j.1528-1157.2003.55902.x |
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