التفاصيل البيبلوغرافية
| العنوان: |
The mean time to reach a detectable viral load at the infection site. |
| المؤلفون: |
Peter Czuppon (8029874), Florence Débarre (265532), Antonio Gonçalves (10213952), Olivier Tenaillon (22050), Alan S. Perelson (7832039), Jérémie Guedj (2549236), François Blanquart (3191950) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Microbiology, Pharmacology, Biotechnology, Immunology, Cancer, Mental Health, Infectious Diseases, Virology, Computational Biology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, action Repurposed drugs, prophylactic treatment, antivirals delay, drug types, drug-specific mechanisms, virus particles, symptom severity, virus infection, efficacy, phase infection |
| الوصف: |
Panel A: Solid lines represent the theoretical prediction of the average time for the viral infection to reach 2, 000 virions (see Section F in S1 Text for details). We used the LowN parameter set to simulate 10, 000 stochastic simulations that reached a viral load of 2, 000 total virus particles when starting with an inoculum of V I (0) = 1. Dots are the average times calculated from these simulations, bars represent 90% of the simulated establishment times. We only consider efficacies below the critical efficacy ( ε j < 0.87, cf. Fig 2A ) because above the critical efficacy infection is never established. Panel B: We plot 10 example trajectories that reach the detectable viral load for each of the four types of treatment (efficacy ε j = 0.75). Under treatment that increases the infected cell death δ or reduces infectivity β , establishing trajectories reach the detectable viral load almost immediately. In contrast, drugs that directly affect the number of virus particles, i.e. clearance c or production p , allow for trajectories that fluctuate much more, explaining the larger average detection times and the larger variation of detection times for these scenarios. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/The_mean_time_to_reach_a_detectable_viral_load_at_the_infection_site_/14137448 |
| DOI: |
10.1371/journal.pcbi.1008752.g004 |
| الاتاحة: |
https://doi.org/10.1371/journal.pcbi.1008752.g004 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.24CAD273 |
| قاعدة البيانات: |
BASE |