Academic Journal
Gold Nanodandelions as Nanozymes and Reactive Oxygen Species Scavengers in Tumor Microenvironment Components
| العنوان: | Gold Nanodandelions as Nanozymes and Reactive Oxygen Species Scavengers in Tumor Microenvironment Components |
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| المؤلفون: | Hsin-Lun Lee, Yao Chen Chuang, Jo-Ting Tsai, Yu-Chen Chen, Ping-Hsiu Wu, Leu-Wei Lo, Jeng-Fong Chiou, Yao-An Shen |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biochemistry, Medicine, Cell Biology, Biotechnology, Cancer, Inorganic Chemistry, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tumor microenvironment modulation, reactive oxygen species, biomedical applications due, attracted increasing attention, scavenging system using, induce oxidative etching, gold nanomaterials regulated, scavenge intracellular ros, 2 , ros scavenging, oxidative stress, gold nanodandelions, gold nanodandelion, ros production, ros ), various cancers, surface passivation, results indicated, provide protection, promising antioxidant, physicochemical properties, normal fibroblasts |
| الوصف: | Gold nanomaterials have attracted increasing attention in biomedical applications due to their biocompatibility and intrinsic optical and physicochemical properties. Oxidative stress, which is mainly contributed by reactive oxygen species (ROS), has been crucial in various cancers and diseases. Here, we report a gold nanodandelion (GND)-based ROS-scavenging system using the antioxidant properties of GNDs. GNDs scavenge superoxide anions and hydroxyl radicals in situ and induce oxidative etching with hydrogen peroxide (H 2 O 2 ). The size and surface passivation of gold nanomaterials regulated the efficiency of ROS scavenging. The differential effect of GNDs to scavenge intracellular ROS was studied through cell viability, nanoparticle uptake, ROS production, and antioxidant enzymes. Results indicated that GNDs in normal fibroblasts and macrophages display minimal toxicity and provide protection from H 2 O 2 -induced oxidative stress. For the first time, GNDs exhibit outstanding nitric oxide (NO • ) generation performance in M1 macrophage. Interestingly, the presence of GNDs in glioma cells attenuated cell proliferation, migration, and invasion behaviors. GNDs are expected to be a promising antioxidant in cancer treatment and tumor microenvironment modulation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Gold_Nanodandelions_as_Nanozymes_and_Reactive_Oxygen_Species_Scavengers_in_Tumor_Microenvironment_Components/24487415 |
| DOI: | 10.1021/acsanm.3c04734.s001 |
| الاتاحة: | https://doi.org/10.1021/acsanm.3c04734.s001 https://figshare.com/articles/journal_contribution/Gold_Nanodandelions_as_Nanozymes_and_Reactive_Oxygen_Species_Scavengers_in_Tumor_Microenvironment_Components/24487415 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.24C4D988 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsanm.3c04734.s001 |
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