Academic Journal
Guidelines for translational research in heart failure
| العنوان: | Guidelines for translational research in heart failure |
|---|---|
| المؤلفون: | Lara-Pezzi, Enrique, Menasché, Philippe, Trouvin, Jean-Hugues, Badimón, Lina, Ioannidis, John P A, Wu, Joseph C, Hill, Joseph A, Koch, Walter J, De Felice, Albert F, de Waele, Peter, Steenwinckel, Valérie, Hajjar, Roger J, Zeiher, Andreas M |
| المساهمون: | Unión Europea. Comisión Europea, Ministerio de Economía y Competitividad (España), Comunidad de Madrid (España), Fundación ProCNIC, Fondation Leducq, National Institutes of Health (Estados Unidos), American Heart Association, Instituto de Salud Carlos III |
| بيانات النشر: | Springer |
| سنة النشر: | 2015 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Animals, Cardiology, Disease Models, Animal, Guidelines as Topic, Humans, Research Design, Translational Medical Research, Heart Failure |
| الوصف: | Heart failure (HF) remains a major cause of death and hospitalization worldwide. Despite medical advances, the prognosis of HF remains poor and new therapeutic approaches are urgently needed. The development of new therapies for HF is hindered by inappropriate or incomplete preclinical studies. In these guidelines, we present a number of recommendations to enhance similarity between HF animal models and the human condition in order to reduce the chances of failure in subsequent clinical trials. We propose different approaches to address safety as well as efficacy of new therapeutic products. We also propose that good practice rules are followed from the outset so that the chances of eventual approval by regulatory agencies increase. We hope that these guidelines will help improve the translation of results from animal models to humans and thereby contribute to more successful clinical trials and development of new therapies for HF. ; European Union [CardioNeT-ITN-289600, CardioNext-ITN-608027, FP7-IMI-JU-SAFET-115003]; Spanish Ministry of Economy [SAF2012-31451]; Regional Government of Madrid [2010-BMD-2321]; Spanish Ministry of Economy; Pro-CNIC Foundation; NIH [HL-120732, HL100401]; AHA [14SFRN20740000]; CPRIT [RP110486P3]; Leducq Foundation [11CVD04]; MINECO-SAF [2013-42962R]; Instituto Carlos III [TERCEL-RD-12/00190026, RIC12/00420024] ; Sí |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1937-5387 1937-5395 |
| Relation: | https://doi.org/10.1007/s12265-015-9606-8; info:eu-repo/grantAgreement/EC/FP7/289600/EU; info:eu-repo/grantAgreement/EC/FP7/608027/EU; info:eu-repo/grantAgreement/EC/FP7/115003/EU; info:eu-repo/grantAgreement/ES/SAF2012-31451; info:eu-repo/grantAgreement/ES/2013-42962R; info:eu-repo/grantAgreement/ES/RD12/0019/0026; info:eu-repo/grantAgreement/ES/RIC12/0042/0024; J Cardiovasc Transl Res. 2015; 8(1):3-22; http://hdl.handle.net/20.500.12105/7982; Journal of cardiovascular translational research |
| DOI: | 10.1007/s12265-015-9606-8 |
| الاتاحة: | https://hdl.handle.net/20.500.12105/7982 https://doi.org/10.1007/s12265-015-9606-8 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.249F05A6 |
| قاعدة البيانات: | BASE |
| تدمد: | 19375387 19375395 |
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| DOI: | 10.1007/s12265-015-9606-8 |