Academic Journal
Long-term dynamics of natural killer cells in response to SARS-CoV-2 vaccination: Persistently enhanced activity postvaccination
| العنوان: | Long-term dynamics of natural killer cells in response to SARS-CoV-2 vaccination: Persistently enhanced activity postvaccination |
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| المؤلفون: | Mele, Dalila, Ottolini, Sabrina, Lombardi, Andrea, Conteianni, Daniela, Bandera, Alessandra, Oliviero, Barbara, Mantovani, Stefania, Cassaniti, Irene, Baldanti, Fausto, Gori, Andrea, Mondelli, Mario U, Varchetta, Stefania |
| المساهمون: | D. Mele, S. Ottolini, A. Lombardi, D. Conteianni, A. Bandera, B. Oliviero, S. Mantovani, I. Cassaniti, F. Baldanti, A. Gori, M.U. Mondelli, S. Varchetta |
| بيانات النشر: | Wiley Blackwell Publishing |
| سنة النشر: | 2024 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | CD107a, NKG2A, NKG2C, SARS‐CoV‐2, natural killer cell, vaccine, Settore MED/17 - Malattie Infettive |
| الوصف: | Natural Killer (NK) cells play a significant role in the early defense against virus infections and cancer. Recent studies have demonstrated the involvement of NK cells in both the induction and effector phases of vaccine-induced immunity in various contexts. However, their role in shaping immune responses following SARS-CoV-2 vaccination remains poorly understood. To address this matter, we conducted a comprehensive analysis of NK cell phenotype and function in SARS-CoV-2 unexposed individuals who received the BNT162b2 vaccine. We employed a longitudinal study design and utilized a panel of 53 15-mer overlapping peptides covering the receptor binding domain (RBD) of the SARS-CoV-2 Spike protein to assess NK cell function at 0 and 20 days following the first vaccine, and 30 and 240 days following booster. Additionally, we evaluated the levels of total IgG anti-Spike antibodies and their potential neutralizing ability. Our findings revealed an increased NK cell activity upon re-exposure to RBD when combined with IL12 and IL18 several months after booster. Concurrently, we observed that the frequencies of NKG2A + NK cells declined over the course of the follow-up period, while NKG2C increased only in CMV positive subjects. The finding that NK cell functions are inducible 9 months after vaccination upon re-exposure to RBD and cytokines, sheds light on the role of NK cells in contributing to SARS-CoV-2 vaccine-induced immune protection and pave the way to further studies in the field. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38566585; volume:96; issue:4; firstpage:1; lastpage:13; numberofpages:13; journal:JOURNAL OF MEDICAL VIROLOGY; https://hdl.handle.net/2434/1049191; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85189648093 |
| DOI: | 10.1002/jmv.29585 |
| الاتاحة: | https://hdl.handle.net/2434/1049191 https://doi.org/10.1002/jmv.29585 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.24855385 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jmv.29585 |
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