التفاصيل البيبلوغرافية
| العنوان: |
Synthesis of 6-azaprogesterone and 19-hydroxy-6-azasteroids |
| المؤلفون: |
Martínez, M.D., Edelsztein, V.C., Durán, F.J., Di Chenna, P.H., Burton, G. |
| المجموعة: |
Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires) |
| مصطلحات موضوعية: |
19-Hydroxypregnane, 6-Azaprogesterone, Azasteroids, Gestagenic activity, 18 hydroxy 20 oxosteroid, 18 hydroxydeoxycorticosterone, 18 hydroxyprogesterone, 19 hydroxy 3 oxosteroid, 19 hydroxy 6 (tert butoxycarbonyl) 6 aza 4 pregnene 3,20 dione, 19 hydroxy 6 azaprogesterone, 19 hydroxy 6 azasteroid, 3beta tert butyldimethylsilyloxy 19 formyloxy 6 aza 5 pregnen 20 one, 3beta tert butyldimethylsilyloxy 6 (tert butoxycarbonyl) 19 formyloxy 6 aza 4 pregnen 20 one, 3beta tert butyldimethylsilyloxy 7 azido 19 formyloxy 6 nor 5,7 secopregnane 5,20 dione, 3beta,19 dihydroxy 6 (tert butoxycarbonyl) 6 aza 4 pregnen 20 one, 6 azaprogesterone, azasteroid, gestagen, manganese dioxide, pregnenolone, progesterone receptor, secosteroid, unclassified drug, acylation, animal cell, article, chemical bond, controlled study, cyclization, drug structure |
| الوصف: |
19-Hydroxy-6-azapregnanes were obtained from pregnenolone via a 7-azido-5-oxo-6-nor-5,7-secopregnane intermediate. The 6-azapregnane core was built in good yield in a straightforward way from the secosteroid, by means of a Staudinger (aza-Wittig) reaction. Finally the 19-hydroxy-6-azapregnane was transformed into 19-hydroxy-6-azaprogesterone (that cyclized spontaneously to the 19 → 3 hemiketal) and 6-azaprogesterone. The 6-azapregnanes lacked agonistic/antagonistic activity on the progesterone receptor. © 2012 Elsevier Inc. All rights reserved. ; Fil:Edelsztein, V.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. ; Fil:Durán, F.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. ; Fil:Di Chenna, P.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. ; Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
| نوع الوثيقة: |
journal/newspaper |
| اللغة: |
unknown |
| Relation: |
http://hdl.handle.net/20.500.12110/paper_0039128X_v78_n1_p34_Martinez |
| الاتاحة: |
https://hdl.handle.net/20.500.12110/paper_0039128X_v78_n1_p34_Martinez |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/2.5/ar |
| رقم الانضمام: |
edsbas.2465A39E |
| قاعدة البيانات: |
BASE |