Academic Journal
Regioselective pyrrolizidine bis-spirooxindoles as efficient anti-amyloidogenic agents
| العنوان: | Regioselective pyrrolizidine bis-spirooxindoles as efficient anti-amyloidogenic agents |
|---|---|
| المؤلفون: | Nilamuni De Silva, Anthony Dahdah, Ewan Blanch, Helmut Hugel, Subashani Maniam |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Biologically active molecules, Organic chemical synthesis, Alzheimer's disease, Amyloid-?, Protein misfolding, Raman spectroscopy, Spirooxindole |
| الوصف: | Here, we report a microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition reaction to produce highly regioselective and stereoselective bis-spirooxindoles as potential inhibitors against amyloid-? fibrillation. Ease of synthesis, promising anti-amyloidogenic activity, low toxicity, and in vitro blood brain barrier permeability makes these compounds attractive therapeutic leads to treat Alzheimer's disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | 10779/rmit.27558105.v1 |
| الاتاحة: | https://figshare.com/articles/journal_contribution/Regioselective_pyrrolizidine_bis-spirooxindoles_as_efficient_anti-amyloidogenic_agents/27558105 |
| Rights: | All rights reserved |
| رقم الانضمام: | edsbas.2457D0D8 |
| قاعدة البيانات: | BASE |
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