التفاصيل البيبلوغرافية
| العنوان: |
Regioselective pyrrolizidine bis-spirooxindoles as efficient anti-amyloidogenic agents |
| المؤلفون: |
Nilamuni De Silva, Anthony Dahdah, Ewan Blanch, Helmut Hugel, Subashani Maniam |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biologically active molecules, Organic chemical synthesis, Alzheimer's disease, Amyloid-?, Protein misfolding, Raman spectroscopy, Spirooxindole |
| الوصف: |
Here, we report a microwave-assisted, one-pot, three-component, 1,3-dipolar cycloaddition reaction to produce highly regioselective and stereoselective bis-spirooxindoles as potential inhibitors against amyloid-? fibrillation. Ease of synthesis, promising anti-amyloidogenic activity, low toxicity, and in vitro blood brain barrier permeability makes these compounds attractive therapeutic leads to treat Alzheimer's disease. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
10779/rmit.27558105.v1 |
| الاتاحة: |
https://figshare.com/articles/journal_contribution/Regioselective_pyrrolizidine_bis-spirooxindoles_as_efficient_anti-amyloidogenic_agents/27558105 |
| Rights: |
All rights reserved |
| رقم الانضمام: |
edsbas.2457D0D8 |
| قاعدة البيانات: |
BASE |