Academic Journal
The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy: A Literature Review
| العنوان: | The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy: A Literature Review |
|---|---|
| المؤلفون: | Headen, K, Jakaite, V, Mesaric, VA, Scottá, C, Lombardi, G, Nicolaides, KH, Shangaris, P |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| المجموعة: | Brunel University London: Brunel University Research Archive (BURA) |
| مصطلحات موضوعية: | Tregs, preeclampsia, hypertensive disorders, immune tolerance, semi-allogeneic foetus |
| الوصف: | Hypertensive disorders of pregnancy (HDP), including preeclampsia (PE) and gestational hypertension (GH), are major causes of maternal and foetal morbidity and mortality. This review elucidates the role of regulatory T cells (Tregs) in the immunological aspects of HDP and explores their therapeutic potential. Tregs, which play a critical role in maintaining immune homeostasis, are crucial in pregnancy to prevent immune-mediated rejection of the foetus. The review highlights that Tregs contribute to immunological adaptation in normal pregnancy, ensuring foetal acceptance. In contrast, HDP is associated with Treg dysfunction, which is marked by decreased numbers and impaired regulatory capacity, leading to inadequate immune tolerance and abnormal placental development. This dysfunction is particularly evident in PE, in which Tregs fail to adequately modulate the maternal immune response against foetal antigens, contributing to the pathophysiology of the disorder. Therapeutic interventions aiming to modulate Treg activity represent a promising avenue for HDP management. Studies in animal models and limited clinical trials suggest that enhancing Treg functionality could mitigate HDP symptoms and improve pregnancy outcomes. However, given the multifactorial nature of HDP and the intricate regulatory mechanisms of Tregs, the review explores the complexities of translating in vitro and animal model findings into effective clinical therapies. In conclusion, while the precise role of Tregs in HDP is still being unravelled, their central role in immune regulation during pregnancy is indisputable. Further research is needed to fully understand the mechanisms by which Tregs contribute to HDP and to develop targeted therapies that can safely and effectively harness their regulatory potential for treating hypertensive diseases of pregnancy. ; P.S. is supported by a Fetal Medicine Foundation Senior Clinical Lectureship and grants from the Fetal Medicine Foundation, Charity number: 1037116. K.H. is supported by a Fetal Medicine ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 - 14; Electronic |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | International Journal of Molecular Sciences; ORCiD: Vaidile Jakaite orcid:0000-0002-4688-5751; ORCiD: Vita Andreja Mesaric orcid:0000-0003-1214-344X; ORCiD: Cristiano Scottá orcid:0000-0003-3942-5201; ORCiD: Panicos Shangaris orcid:0000-0003-2750-8405; 4884; Headen, K. et al. (2024) 'The Role of Regulatory T Cells and Their Therapeutic Potential in Hypertensive Disease of Pregnancy: A Literature Review', International Journal of Molecular Sciences, 25 (9), 4884, pp. 1 - 14. doi:10.3390/ijms25094884.; https://bura.brunel.ac.uk/handle/2438/29191; https://doi.org/10.3390/ijms25094884 |
| DOI: | 10.3390/ijms25094884 |
| الاتاحة: | https://bura.brunel.ac.uk/handle/2438/29191 https://doi.org/10.3390/ijms25094884 |
| Rights: | Copyright © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). ; https://creativecommons.org/licenses/by/4.0/ ; https://creativecommons.org/licenses/by/4.0/legalcode.en ; The authors |
| رقم الانضمام: | edsbas.2452F179 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
|---|---|
| DOI: | 10.3390/ijms25094884 |