Academic Journal
Reducing antipsychotic drugs in stable patients with chronic schizophrenia or schizoaffective disorder: a randomized controlled pilot trial
| العنوان: | Reducing antipsychotic drugs in stable patients with chronic schizophrenia or schizoaffective disorder: a randomized controlled pilot trial |
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| المؤلفون: | Huhn, Maximilian, Leucht, Claudia, Rothe, Philipp, Dold, Markus, Heres, Stephan, Bornschein, Susanne, Schneider-Axmann, Thomas, Hasan, Alkomiet, Leucht, Stefan |
| المصدر: | http://lobid.org/resources/99370671259506441#!, 271(2):293-302. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Female [MeSH], Antipsychotic Agents/administration, Chronic schizophrenia, Antipsychotic Agents/adverse effects [MeSH], Adult [MeSH], Humans [MeSH], Randomized clinical trial, Severity of Illness Index [MeSH], Antipsychotic maintenance treatment, Middle Aged [MeSH], Schizophrenia/drug therapy [MeSH], Dose reduction, Feasibility Studies [MeSH], Psychotic Disorders/drug therapy [MeSH], Recurrence [MeSH], Male [MeSH], Chronic Disease [MeSH], Original Paper, Pilot Projects [MeSH], Single-Blind Method [MeSH], Relapse, Outcome Assessment, Health Care [MeSH] |
| الوصف: | As the course of schizophrenic disorders is often chronic, treatment guidelines recommend continuous maintenance treatment to prevent relapses, but antipsychotic drugs can cause many side effects. It, therefore, seems reasonable to try to reduce doses in stable phases of the illness or even try to stop medication. We conducted a 26 weeks, randomized, rater blind, feasibility study to examine individualized antipsychotic dose reduction versus continuous maintenance treatment (Register Number: NCT02307396). We included chronic, adult patients with schizophrenia or schizoaffective disorder, who were treated with any antipsychotic drug except clozapine, who had not been hospitalized in the last 3 years and who were in symptomatic remission at baseline. The primary outcome was relapse of positive symptoms. Symptom severity, social functioning and side effects were also examined as secondary outcomes. 20 patients were randomized. Relapse rates in the two groups were not significantly different. No patient had to be hospitalized. One patient in the control group dropped out. The mean reduction of antipsychotic dose in the individualized dose-reduction group was 42%, however only one patient discontinued drug completely. There were no significant differences in efficacy or safety outcomes. This randomized trial provides evidence, that reduction of antipsychotic medication in chronic stable schizophrenic patients may be feasible. The results need to be confirmed in a larger trial with a longer follow-up period. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6467442; https://doi.org/10.1007/s00406-020-01109-y; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960583/ |
| DOI: | 10.1007/s00406-020-01109-y |
| الاتاحة: | https://repository.publisso.de/resource/frl:6467442 https://doi.org/10.1007/s00406-020-01109-y https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960583/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.243D240C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00406-020-01109-y |
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