Dissertation/ Thesis
Lung function, sleep-related breathing and respiratory infections after allogeneic stem cell transplantation in childhood ; Allogeenisen kantasolusiirron vaikutukset lasten keuhkojen toimintaan, hengitystieinfektioihin ja unenaikaiseen hengitykseen.
| العنوان: | Lung function, sleep-related breathing and respiratory infections after allogeneic stem cell transplantation in childhood ; Allogeenisen kantasolusiirron vaikutukset lasten keuhkojen toimintaan, hengitystieinfektioihin ja unenaikaiseen hengitykseen. |
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| المؤلفون: | Ukonmaanaho, Elli-Maija |
| المساهمون: | Helsingin yliopisto, lääketieteellinen tiedekunta, Helsingfors universitet, medicinska fakulteten, University of Helsinki, Faculty of Medicine, Remes, Kari, Taskinen, Mervi, Koskenvuo, Minna |
| بيانات النشر: | Helsingin yliopisto Helsingfors universitet University of Helsinki |
| سنة النشر: | 2024 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | lääketiede, Doctoral Program in Clinical Research, Kliininen tohtoriohjelma, Doktorandprogrammet i klinisk forskning, 3122 Syöpätaudit, 3123 Naisten- ja lastentaudit, 3122 Cancersjukdomar, 3123 Kvinno- och barnsjukdomar, 3122 Cancers, 3123 Gynaecology and paediatrics |
| الوصف: | Over the past two decades, allogeneic haematopoietic stem cell transplantation (HSCT) has established its position as part of the treatment for many childhood malignant and non-malignant diseases of the bone marrow and immune system. At the Helsinki Children’s Hospital, approximately 20–25 allogeneic stem cell transplants are performed annually for paediatric patients. Complications following allogeneic stem cell transplantation typically relate to infections and the development of graft-versus-host disease (GvHD), which is caused by differences in human leukocyte antigens between the donor and the recipient. GvHD can be classified as acute or chronic. One of the most challenging forms of chronic GvHD is chronic GvHD of the lungs, which causes significant morbidity and mortality. There is limited research on the diagnosis, treatment or monitoring of pulmonary GvHD manifestations, with existing research primarily focusing on the adult population. This study aimed to investigate the clinical presentation and diagnosis of GvHD of the lungs, most importantly bronchiolitis obliterans syndrome (BOS). As pulmonary function changes related to BOS are often irreversible, it is important to identify patients at an early stage to plan the appropriate follow-up of pulmonary function tests after allogeneic stem cell transplantation. There is a significant decline in lung function tests early post-HSCT in children with chronic respiratory symptoms after allogeneic HSCT. The histological findings of BOS correlated closely with pulmonary function tests, showing early signs of obstructive lung function and a mosaic pattern in lung high-resolution computed tomography scans. Paediatric allogeneic HSCT patients with severe chronic GvHD of the lungs and obstructive lung function face a substantial risk of sleep-related breathing disorders, indicated by a ventilation–perfusion mismatch, increased breathing effort and hypoventilation during rapid eye movement (REM) sleep. BOS patients experienced increased work of breathing during ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf; fulltext |
| اللغة: | English |
| ردمك: | 978-952-84-0165-0 952-84-0165-1 |
| تدمد: | 2954-2898 2954-2952 |
| Relation: | Dissertationes Universitatis Helsingiensis; 215/2024; http://hdl.handle.net/10138/587537 |
| الاتاحة: | http://hdl.handle.net/10138/587537 |
| Rights: | Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. ; This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. ; Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. |
| رقم الانضمام: | edsbas.24004BED |
| قاعدة البيانات: | BASE |
| ردمك: | 9789528401650 9528401651 |
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| تدمد: | 29542898 29542952 |