التفاصيل البيبلوغرافية
| العنوان: |
A mouse peritonitis model for the study of glycopeptide efficacy in GISA infections |
| المؤلفون: |
Doménech Ariza, Alejandro, Ribes Miravet, Sandra, Cabellos Mínguez, Ma. Carmen, Domínguez Luzón, Ma. Ángeles (María Ángeles), Montero Saez, Abelardo, Liñares Louzao, Josefina, Ariza Cardenal, Javier, Gudiol i Munté, Francesc |
| المصدر: |
Articles publicats en revistes (Ciències Clíniques) |
| بيانات النشر: |
Mary Ann Liebert, Inc. |
| سنة النشر: |
2004 |
| المجموعة: |
Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: |
Infeccions per estafilococs, Antibiòtics, Ratolins (Animals de laboratori), Medicaments antibacterians, Resistència als medicaments, Peritonitis, Staphylococcal infections, Antibiotics, Mice (Laboratory animals), Antibacterial agents, Drug resistance |
| الوصف: |
In recent years, the emergence of Staphylococcus aureus strains with reduced susceptibility to glycopeptides has raised considerable concern. We studied the efficacy of vancomycin and teicoplanin, as well as cloxacillin and cefotaxime, against the infection caused by four S. aureus strains with different glycopeptide and β-lactam susceptibilities (strains A, B, C, and D; MICs for vancomycin of 1, 2, 4, and 8 µg/ml respectively), using a modified model of mouse peritonitis. This optimized model appeared to be straightforward and reproducible, and was able to detect low differences in bacterial killing between antibiotics and also between different S. aureus strains. Bactericidal activities in peritoneal fluid for vancomycin, teicoplanin, cloxacillin, and cefotaxime decreased from -2.98, -2.36, -3.22, and -3.57 log10 cfu/ml, respectively, in infection by strain A (MICs for vancomycin and cloxacillin of 1 and 0.38 µg/ml, respectively) to -1.22, -0.65, -1.04, and +0.24 in peritonitis due to strain D (MICs for vancomycin and cloxacillin of 8 and 1,024 µg/ml). Our data confirm the superiority of β-lactams against methicillin-susceptible S. aureus and show that bactericidal activity of glycopeptides decreases significantly with slight increases in MICs; this finding suggests a reduced efficacy of glycopeptides in the treatment of serious glycopeptide-intermediate S. aureus infections |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
8 p.; application/pdf |
| اللغة: |
English |
| تدمد: |
1076-6294 |
| Relation: |
Reproducció del document publicat a: http://dx.doi.org/10.1089/mdr.2004.10.346; Microbial Drug Resistance, 2004, vol. 10, num. 4, p. 346-353; http://dx.doi.org/10.1089/mdr.2004.10.346; http://hdl.handle.net/2445/55248; 532586 |
| الاتاحة: |
http://hdl.handle.net/2445/55248 |
| Rights: |
(c) Mary Ann Liebert, Inc., 2004 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.23C80E24 |
| قاعدة البيانات: |
BASE |