Academic Journal
Peripheral T-cell lymphomas with a follicular growth pattern are derived from follicular helper T cells (TFH) and may show overlapping features with angioimmunoblastic T-cell lymphomas.
| العنوان: | Peripheral T-cell lymphomas with a follicular growth pattern are derived from follicular helper T cells (TFH) and may show overlapping features with angioimmunoblastic T-cell lymphomas. |
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| المؤلفون: | Huang, Yenlin, Moreau, Anne, Dupuis, Jehan, Streubel, Berthold, Petit, Barbara, Le Gouill, Steven, Martin-Garcia, Nadine, Copie-Bergman, Christiane, Gaillard, Fanny, Qubaja, Marwan, Fabiani, Bettina, Roncador, Giovanna, Haioun, Corinne, Delfau-Larue, Marie-Hélène, Marafioti, Teresa, Chott, Andreas, Gaulard, Philippe |
| المساهمون: | Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Département de pathologie Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service d'hématologie clinique, Departement of Pathology, Medizinische Universität Wien = Medical University of Vienna, Service d'Hématologie biologique CHU Limoges, CHU Limoges, Hôpital Hôtel-Dieu Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Pathologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu, CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Monoclonal antibodies unit, Centro Nacional de Investigaciones Oncológicas, Service d'immunologie biologique, Leukaemia Research Immunodiagnostics Unit, University of Oxford-John Radcliffe Hospital Oxford University Hospital |
| المصدر: | ISSN: 0147-5185 ; American Journal of Surgical Pathology ; https://inserm.hal.science/inserm-00385332 ; American Journal of Surgical Pathology, 2009, 33 (5), pp.682-90. ⟨10.1097/PAS.0b013e3181971591⟩. |
| بيانات النشر: | CCSD Lippincott, Williams & Wilkins |
| سنة النشر: | 2009 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma, follicular helper T cell, MESH: Adult, MESH: Aged, MESH: Chromosomes, Human, Pair 9, MESH: DNA-Binding Proteins, MESH: Europe, MESH: Gene Expression Regulation, Neoplastic, MESH: Gene Rearrangement, T-Lymphocyte, MESH: Genotype, MESH: Humans, MESH: Immunoblastic Lymphadenopathy, MESH: Immunophenotyping, MESH: In Situ Hybridization, Fluorescence, 80 and over, MESH: Lymphoma, Follicular, T-Cell, Peripheral, MESH: Middle Aged, MESH: Neoplasm Staging, MESH: Neprilysin, MESH: Phenotype, MESH: T-Lymphocytes |
| الوصف: | International audience ; Rare cases of peripheral T-cell lymphomas with follicular growth pattern (PTCL-F) have been recently reported, and their association with t(5;9)(q33;q22) involving ITK and SYK has been suggested. However, the clinicopathologic aspects of PTCL-F are poorly described and the normal cell counterpart of this subgroup of lymphoma is still unknown. Therefore, we analyzed the pathologic, phenotypic, and cytogenetic features of a series of 30 patients (range: 33 to 88 y) that showed histopathologic features of PTCL-F in at least 1 biopsy (n=30), either at initial presentation (n=26) or at relapse (n=4). Neoplastic cells were medium-sized clear cells that were CD4+ (24/27, 89%), CD10+ (21/29, 72%), BCL-6+ (14/19, 74%), and expressed programed death-1 (27/27, 100%), CXCL13 (23/27, 85%), and ICOS (11/11, 100%), markers of follicular helper T cells (TFH). Four of 22 patients (18%) had t(5;9)(q33;q22) detected by fluorescence in situ hybridization. Patients with clinical data available had multiple lymphadenopathies (25/28, 89%), stage III to IV diseases (17/26, 65%), B symptoms (7/27, 26%), and skin lesions (6/23, 26%). Three patients with sequential biopsies disclosed clinical and histopathologic features of angioimmunoblastic T-cell lymphoma at initial presentation. Our results show that this rare form of PTCL-F (1) has an immunophenotype indicative of derivation from TFH cells, (2) is associated with t(5;9) in a proportion of cases, and (3) shows some overlapping features with angioimmunoblastic T-cell lymphoma, raising the question of a possible relationship. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/19295409; PUBMED: 19295409; PUBMEDCENTRAL: PMC4838638 |
| DOI: | 10.1097/PAS.0b013e3181971591 |
| الاتاحة: | https://inserm.hal.science/inserm-00385332 https://inserm.hal.science/inserm-00385332v1/document https://inserm.hal.science/inserm-00385332v1/file/AJSP-D-08-00174R2.pdf https://doi.org/10.1097/PAS.0b013e3181971591 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.238E264F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/PAS.0b013e3181971591 |
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