Academic Journal
Detection of the ‘Big Five’ mold killers of humans: Aspergillus, Fusarium, Lomentospora, Scedosporium and Mucormycetes
| العنوان: | Detection of the ‘Big Five’ mold killers of humans: Aspergillus, Fusarium, Lomentospora, Scedosporium and Mucormycetes |
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| المؤلفون: | Thornton, CR |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | University of Exeter: Open Research Exeter (ORE) |
| مصطلحات موضوعية: | Aspergillus, aspergillosis, Fusarium, Lomentospora, Scedosporium, mucormycosis, monoclonal antibody, lateral-flow device, fungal diagnostics, mycoses |
| الوصف: | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record ; Fungi are an important but frequently overlooked cause of morbidity and mortality in humans. Life-threatening fungal infections mainly occur in immunocompromised patients, and are typically caused by environmental opportunists that take advantage of a weakened immune system. The filamentous fungus Aspergillus fumigatus is the most important and well-documented mould pathogen of humans, causing a number of complex respiratory diseases, including invasive pulmonary aspergillosis, an often fatal disease in patients with acute leukemia or in immunosuppressed bone marrow or solid organ transplant recipients. However, non-Aspergillus moulds are increasingly reported as agents of disseminated diseases, with Fusarium, Scedosporium, Lomentospora and mucormycete species now firmly established as pathogens of immunosuppressed and immunocompetent individuals. Despite well-documented risk factors for invasive fungal diseases, and increased awareness of the risk factors for life-threatening infections, the number of deaths attributable to moulds is likely to be severely underestimated driven, to a large extent, by the lack of readily accessible, cheap, and accurate tests that allow detection and differentiation of infecting species. Early diagnosis is critical to patient survival but, unlike Aspergillus diseases, where a number of CE-marked or FDA-approved biomarker tests are now available for clinical diagnosis, similar tests for fusariosis, scedosporiosis and mucormycosis remain experimental, with detection reliant on insensitive and slow culture of pathogens from invasive bronchoalveolar lavage fluid, tissue biopsy, or from blood. This review examines the ecology, epidemiology, and contemporary methods of detection of these mould pathogens, and the obstacles to diagnostic test development and translation of novel biomarkers to the clinical setting. ; Innovate UK |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Published online 20 November 2019; 105440; http://hdl.handle.net/10871/39483; Advances in Applied Microbiology |
| DOI: | 10.1016/bs.aambs.2019.10.003 |
| الاتاحة: | http://hdl.handle.net/10871/39483 https://doi.org/10.1016/bs.aambs.2019.10.003 |
| Rights: | © 2019. This version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ ; 2020-11-20 ; Under embargo until 20 November 2020 in compliance with publisher policy ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.237E56C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/bs.aambs.2019.10.003 |
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