التفاصيل البيبلوغرافية
| العنوان: |
Clinical aspects of heat-labile and heat-stable toxin-producing enterotoxigenic Escherichia coli : A prospective study among Finnish travellers |
| المؤلفون: |
Turunen, Katri, Antikainen, Jenni, Lääveri, Tinja, Kirveskari, Juha, Svennerholm, Ann-Mari, Kantele, Anu |
| المساهمون: |
Department of Medicine, Department of Bacteriology and Immunology, HUS Inflammation Center, Infektiosairauksien yksikkö, Helsinki University Hospital Area, HUSLAB, Clinicum, Department of Diagnostics and Therapeutics |
| بيانات النشر: |
ELSEVIER SCI IRELAND LTD |
| سنة النشر: |
2021 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
ETEC, LT, ST, STh, STp, Travellers' diarrhoea, COLONIZATION FACTORS, YOUNG-CHILDREN, MILITARY PERSONNEL, DISEASE BURDEN, ACUTE DIARRHEA, US TRAVELERS, DOUBLE-BLIND, PATHOGENS, STRAINS, INFANTS, General medicine, internal medicine and other clinical medicine, Public health care science, environmental and occupational health |
| الوصف: |
Background: Enterotoxigenic Escherichia coli (ETEC) is a major pathogen causing travellers' diarrhoea (TD) among visitors to low- and middle-income countries (LMIC). Scant data are available on rates of travel-acquired ETEC producing heat-labile (LT) and/or heat-stable (ST) toxin or its subtypes, STh (human) and STp (porcine) in various geographic regions, and on clinical pictures associated with each toxin. Methods: Using qPCR, we analysed LT, STh, and STp in stools positive for ETEC in a prospective study among 103 Finnish travellers visiting LMIC. They filled in questionnaires and provided stool samples before and after travel. We scrutinized geographic distribution of LT, STh, and STp ETEC findings, and association between these different ETEC subtypes and moderate/severe TD. Results: Among the 103 stool samples positive for ETEC toxins, the rate for LT was 76%, for STh 26%, and STp 41%. The rate for LT-only was 44%, for 5Th-only 6%, STp-only 16%, LT + STh 10%, LT + STp 15%, STh + STp 3%, and LT + STh + STp 8%. Findings varied by destination; the rates of LT, STh, and STp were 79%, 21%, and 57%, respectively, in Southern Asia (n = 14); 85%, 10%, and 20% in South-eastern Asia (n = 20); 84%, 13%, and 29% in Eastern Africa (n = 31); and 56%, 50%, and 63% in Western Africa (n = 32), respectively. Of travellers positive for LT, STh, and STp, 83%, 100%, and 88%, encountered TD; 35%, 55%, and 41% reported moderate/severe TD. STh was associated with moderate/severe TD. Conclusions: Toxin findings varied by destination; multiple toxins were commonly detected. Moderate/severe TD was reported most frequently by subjects with STh-ETEC. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
This work was supported by a Finnish Government Subsidy for Health Science Research (grant numbers: TYH 2012141, TYH 2013218 and TYH 2014216), the SSAC Foundation (grant number SLS-504141) and the Paulo Foundation. We express our gratitude to the late Dr Jukka Riutta and the nurses at the Travel Clinic of Aava Medical Centre for help in recruiting the volunteers.; Turunen , K , Antikainen , J , Lääveri , T , Kirveskari , J , Svennerholm , A-M & Kantele , A 2020 , ' Clinical aspects of heat-labile and heat-stable toxin-producing enterotoxigenic Escherichia coli : A prospective study among Finnish travellers ' , Travel medicine and infectious disease , vol. 38 , 101855 . https://doi.org/10.1016/j.tmaid.2020.101855; ORCID: /0000-0002-1272-081X/work/87353142; http://hdl.handle.net/10138/324924; 6291880b-242c-4dca-b7eb-4dfecc4b783d; 000600738600021 |
| الاتاحة: |
http://hdl.handle.net/10138/324924 |
| Rights: |
cc_by_nc_nd ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.23548620 |
| قاعدة البيانات: |
BASE |