Academic Journal
Clinical Characteristics and Relevance of Oral Candida Biofilm in Tongue Smears
| العنوان: | Clinical Characteristics and Relevance of Oral Candida Biofilm in Tongue Smears |
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| المساهمون: | Eunae Cho, YounJung Park, Ki-Yeol Kim, Dawool Han, Hyun Sil Kim, Jeong-Seung Kwon, Hyung-Joon Ahn, Kwon, Jeong Seung |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Candida, atrophic candidiasis, biofilm, erythematous candidiasis, hyphae, oral candidiasis, smears, tongue |
| الوصف: | Dimorphic Candida exist as commensal yeast carriages or infiltrate hyphae in the oral cavity. Here, we investigated the clinical relevance of Candida hyphae in non-pseudomembranous oral candidiasis (OC) by smears of tongue biofilms. We conducted a retrospective study of 2829 patients who had had tongue smears regardless of OC suspicion. Clinical characteristics were evaluated using a novel method of assessing hyphae. Clinical factors (moderate/severe stimulated pain, pain aggravated by stimulation, tongue dorsum appearance and initial topical antifungal use) were highly significant in the high-grade hyphae group but were statistically similar in the low-grade hyphae and non-observed hyphae group, suggesting low-grade hyphae infection as a subclinical OC state. In addition to erythematous candidiasis (EC), a new subtype named "morphologically normal symptomatic candidiasis" (MNSC) with specific pain patterns and normal tongue morphology was identified. MNSC had a significantly higher proportion of moderate and severe stimulated pain cases than EC. Low unstimulated salivary flow rate (<0.1 mL/min) was found to be a common risk factor in MNSC and EC. In non-pseudomembranous OC, pain patterns were dependent on Candida hyphae degree regardless of tongue dorsum morphology. Morphologic differences seen in high-grade hyphae infection were not associated with systemic diseases or nutritional deficiencies. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2309-608X |
| Relation: | JOURNAL OF FUNGI; J04005; OAK-2021-01058; https://ir.ymlib.yonsei.ac.kr/handle/22282913/182325; T202101010; JOURNAL OF FUNGI, Vol.7(2) : 77, 2021-01 |
| DOI: | 10.3390/jof7020077 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182325 https://doi.org/10.3390/jof7020077 |
| Rights: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.22F68636 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2309608X |
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| DOI: | 10.3390/jof7020077 |