Dissertation/ Thesis
Sensor Systems for Impaired Healing Markers, Concepts and Applications for Objective Wound Assessment ; Sensor Systeme für chronische Wunden Marker, Konzepte und Anwendungen für objektive Wundbewertung
| العنوان: | Sensor Systems for Impaired Healing Markers, Concepts and Applications for Objective Wound Assessment ; Sensor Systeme für chronische Wunden Marker, Konzepte und Anwendungen für objektive Wundbewertung |
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| المؤلفون: | Puchberger, Dietmar |
| المساهمون: | Vellekoop, Michael J., Keplinger, Franz |
| بيانات النشر: | Universität Bremen Physik/Elektrotechnik (FB 01) |
| سنة النشر: | 2016 |
| المجموعة: | State and University Library Bremen: Electronic Library (E-LIB) |
| مصطلحات موضوعية: | Wound, Healing, Sensor, Microfluidic, pH, Tissue absorption, MMP-9, Infection, Bacteria, Bioburden, Antibiotic testing, 620 Engineering, ddc:620 |
| Time: | 620 |
| الوصف: | In the pathological healing of chronic wounds the ordered sequence of tissue restoration is disturbed. As a consequence, chronic wounds fail to heal within months and pose a major impact on the patient by pain, odor, leakage, and the risk of infection and the health care system by its constant treatment. Introducing objective wound assessment by sensor technology into clinical routine would help to guide treatment procedures and improve the healing outcome. The aim of this research study was the development of simple and effective concepts to evaluate the wound status at the point of care. Requirements for point of care testing include a fast and flexible device use by untrained personal, reduced time and costs, as well as reliable and easy to interpret results. The complex nature of wounds can be divided into the different regimes of physical appearance, biochemical status and microbiological environment, which influence each other. Each regime is tackled separately in this work by identifying possible parameters for wound analysis from the literature and the design of sensor concepts to quantify these candidates. A miniaturized, wearable sensor system for the integration in a wound dressing was developed to collect healing relevant, physiological data. The sensor measures optical reflectance, heart rate, arterial oxigenation, surface pH, moisture and temperature. The function of the sensor system was verified in a porcine wound model. A combination of surface pH, reflected infrared, and red light showed to be the most significant parameter, associated with the healing progress. For the measurement of biochemical parameters a microfluidic platform for the preparation of biosensing hydrogels by in situ polymerization was designed. Introducing functional structures for gel patterning in the chip fabrication allows for rapid assay customization. Simple handling and functionality were illustrated by assays for matrix metalloproteinase, an important factor in chronic wound healing. In addition, the demonstrated ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://media.suub.uni-bremen.de/handle/elib/1062; urn:nbn:de:gbv:46-00105319-19 |
| الاتاحة: | https://media.suub.uni-bremen.de/handle/elib/1062 https://nbn-resolving.org/urn:nbn:de:gbv:46-00105319-19 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.22DD071E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |