Academic Journal
Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves
| العنوان: | Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves |
|---|---|
| المؤلفون: | Rafael Henrique Oliveira Lopes, Luis Fernando Benitez Macorini, Katia Ávila Antunes, Priscilla Pereira de Toledo Espindola, Tamaeh Monteiro Alfredo, Paola dos Santos da Rocha, Zefa Valdivina Pereira, Edson Lucas dos Santos, Kely de Picoli Souza |
| المصدر: | Oxidative Medicine and Cellular Longevity, Vol 2016 (2016) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2016 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Cytology, QH573-671 |
| الوصف: | High levels of reactive oxygen species in the body and hyperlipidemia are key factors for the development of cardiovascular diseases such as atherosclerosis. The present study investigated the antioxidant and hypolipidemic activity of hydroethanolic extract of Curatella americana L. leaves (ExC). The antioxidant activity of ExC was assessed by 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging capacity and protection against hemolysis induced by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH), followed by quantification of malondialdehyde (MDA). Wistar rats with hyperlipidemia induced by high-fructose diet (60%) were treated for 60 days with water, simvastatin (30 mg·Kg−1), ciprofibrate (2 mg·Kg−1), and ExC (200 mg·Kg−1). ExC revealed IC50 of 6.0±0.5 μg·mL−1, an intermediary value among positive controls used in the assay of DPPH scavenging capacity. At all concentrations (50 to 125 μg·mL−1) and times (60 to 240 min) evaluated, ExC protected erythrocytes against AAPH-induced hemolysis, which was confirmed by lower MDA levels. In vivo tests showed a reduction of 34 and 45%, respectively, in serum concentration of cholesterol and triglycerides in hyperlipidemic rats treated with ExC, a similar effect compared to the reference drugs, simvastatin and ciprofibrate, respectively. Together, the results showed the antioxidant activity of ExC and its ability to improve the serum lipid profile in hyperlipidemic rats. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1942-0900 1942-0994 |
| Relation: | http://dx.doi.org/10.1155/2016/9681425; https://doaj.org/toc/1942-0900; https://doaj.org/toc/1942-0994; https://doaj.org/article/3624217e5af54c16baa389a9771f2c9f |
| DOI: | 10.1155/2016/9681425 |
| الاتاحة: | https://doi.org/10.1155/2016/9681425 https://doaj.org/article/3624217e5af54c16baa389a9771f2c9f |
| رقم الانضمام: | edsbas.22D85F0C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19420900 19420994 |
|---|---|
| DOI: | 10.1155/2016/9681425 |