Academic Journal
Plasma Exchange Downregulates Activated Monocytes and Restores Regulatory T Cells in Kawasaki Disease
| العنوان: | Plasma Exchange Downregulates Activated Monocytes and Restores Regulatory T Cells in Kawasaki Disease |
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| المؤلفون: | Koizumi, Keiichi, Hoshiai, Minako, Moriguchi, Takeshi, Katsumata, Nobuyuki, Toda, Takako, Kise, Hiroaki, Hasebe, Yohei, Kono, Yosuke, Sunaga, Yuto, Yoshizawa, Masashi, Watanabe, Atsushi, Harii, Norikazu, Goto, Junko, Kagami, Keiko, Abe, Masako, Matsuda, Kenichi, Sugita, Kanji |
| المساهمون: | Yamanashi Kawasaki Disease Research Group |
| المصدر: | Therapeutic Apheresis and Dialysis ; volume 23, issue 1, page 92-98 ; ISSN 1744-9979 1744-9987 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | In Kawasaki disease (KD), the effect of plasma exchange (PE) on immune cells has not been fully elucidated. Therefore, we examined the changes in the number of CD14 + CD16 + activated monocytes, regulatory T (T reg ), and T‐helper type 17 (Th17) cells in KD patients treated with PE. The percentage of total monocytes and subclasses of lymphocytes, including CD4 + and CD8 + T cells, and CD19 + B cells, showed no significant difference before and after PE. However, the percentage of CD14 + CD16 + monocytes in total leukocytes decreased significantly after PE (1.1% ± 1.5% vs. 2.1% ± 2.3%, P < 0.05). Furthermore, while the percentage of Th17 cells in CD4 + T cells did not change, the percentage of T reg cells in CD4 + T cells increased significantly after PE (11.1% ± 5.1% vs. 8.0% ± 4.4%, P < 0.05). Therefore, PE downregulates activated monocytes and upregulates T reg cells toward normal levels and thus attenuates inflammation in KD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/1744-9987.12754 |
| الاتاحة: | http://dx.doi.org/10.1111/1744-9987.12754 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2F1744-9987.12754 https://onlinelibrary.wiley.com/doi/pdf/10.1111/1744-9987.12754 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.22CD753 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/1744-9987.12754 |
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