Academic Journal
Monotherapy for low-risk gestational trophoblastic neoplasia with score 5-6
| العنوان: | Monotherapy for low-risk gestational trophoblastic neoplasia with score 5-6 |
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| المؤلفون: | Kemin, Li, Mengpei, Zhang, Rutie, Yin |
| المصدر: | Frontiers in Oncology ; volume 12 ; ISSN 2234-943X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Objective To investigate the monotherapy for gestational trophoblastic neoplasia (GTN) patients with FIGO/WHO prognostic score of 5–6. Methods The low-risk GTN patients from 2012 to 2019 were enrolled. The study is a retrospective report to analyze the efficacy and safety of single-agent chemotherapy and combination chemotherapy in patients with a high FIGO/WHO prognostic score of 5–6. Results 75 cases (33.5%) were included. Complete remission was in all patients. Among the 29 cases taking single-agent chemotherapy, 22 cases (75.9%) developed drug resistance. Among the 46 cases taking combination chemotherapy, 7 patients (15.2%) developed drug resistance. There was a statistically significant difference in the drug resistance rate between these two subgroups (P < 0.05), but there was not statistically significant difference in the total number of chemotherapy courses (<2mIU/ml) (P < 0.05). Conclusion Monotherapy showed remarkable advantages in GTN patients with FIGO/WHO prognostic score of 5–6. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fonc.2022.1035170 |
| DOI: | 10.3389/fonc.2022.1035170/full |
| الاتاحة: | http://dx.doi.org/10.3389/fonc.2022.1035170 https://www.frontiersin.org/articles/10.3389/fonc.2022.1035170/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.22886B5F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2022.1035170 |
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