التفاصيل البيبلوغرافية
| العنوان: |
Reduced Expression of PD-1 in Circulating CD4+ and CD8+ Tregs Is an Early Feature of RRMS |
| المؤلفون: |
Maja Machcińska, Magdalena Kierasińska, Martyna Michniowska, Marta Maruszewska-Cheruiyot, Ludmiła Szewczak, Rafał Rola, Anna Karlińska, Michael Stear, Katarzyna Donskow-Łysoniewska |
| المصدر: |
International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 3185 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
T cells, suppressive markers, cytokines, relapsing–remitting multiple sclerosis |
| جغرافية الموضوع: |
agris |
| الوصف: |
Altered regulatory T cell (Treg) function could contribute to MS. The expression of activating and inhibitory receptors influences the activity of Tregs. Our aim was to investigate T cell phenotypes in relapsing–remitting MS (RRMS) patients at an early phase of the disease. We examined the influence of demographic parameters on the distribution of CD4+ and CD8+ T cell subclasses by generalized linear modeling. We also studied the expression of the following markers—CTLA-4, GITR, PD-1, FoxP3, Helios, CD28, CD62L, CD103—on T cell subsets from peripheral blood with a 14-color flow cytometry panel. We used an antibody array to define the profiles of 34 Th1/Th2/Th17 cytokines in the serum. Expression of PD-1 and GITR on CD4+ and CD8+ Tregs was decreased in RRMS patients. The proinflammatory factors IFN-γ, IL-17, IL-17F, TGFβ-1, TGFβ-3, IL-1SRII, IL-12 p40, sgp130, IL-6sR were significantly increased in RRMS patients. Therefore, a deficiency of PD-1 and GITR immune checkpoints on CD4+ and CD8+ Tregs is a feature of RRMS and might underlie impaired T cell control. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Immunology; https://dx.doi.org/10.3390/ijms23063185 |
| DOI: |
10.3390/ijms23063185 |
| الاتاحة: |
https://doi.org/10.3390/ijms23063185 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.2283AE8D |
| قاعدة البيانات: |
BASE |