التفاصيل البيبلوغرافية
| العنوان: |
Hepatoprotective Glucosyloxybenzyl 2‑Hydroxy-2-isobutylsuccinates from Pleione yunnanensis |
| المؤلفون: |
Shao-wei Han (10170739), Xiao-juan Wang (4668427), Bao-song Cui (10170742), Hua Sun (406210), Hui Chen (28597), Daneel Ferreira (1320120), Shuai Li (65944), Mark T. Hamann (1336950) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Inorganic Chemistry, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, hepatoprotective activity, 10 μ M, NMR, 2-isobutylsuccinate, Compound, toxicity, cf, APAP, HepG 2 cells, Pleione yunnanensis, cell viability, bicyclol, HL -7702 cells, model group, HRESIMS |
| الوصف: |
Nine new glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates, pleionosides M–U ( 1 – 9 ), and 12 known compounds ( 10 – 21 ) were isolated from the pseudobulbs of Pleione yunnanensis . Their structures and absolute configurations were established through a combination of HRESIMS and NMR data and supported by physical and chemical methods. Compounds 5 , 6 , 10 , and 15 showed significant in vitro hepatoprotective activity against d-galactosamine (d-GalN)-induced toxicity in HL-7702 cells with increasing cell viability by 27%, 22%, 19%, and 31% compared to the model group (cf. bicyclol, 14%) at 10 μM, respectively. Compounds 4 , 9 , and 11 exhibited moderate hepatoprotective activity against N -acetyl- p -aminophenol (APAP)-induced toxicity in HepG2 cells with increasing cell viability by 9%, 16%, and 12% compared to the model group (cf. bicyclol, 9%) at 10 μM, respectively. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Hepatoprotective_Glucosyloxybenzyl_2_Hydroxy-2-isobutylsuccinates_from_i_Pleione_yunnanensis_i_/14067115 |
| DOI: |
10.1021/acs.jnatprod.0c01117.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.jnatprod.0c01117.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.227BC4B5 |
| قاعدة البيانات: |
BASE |