Academic Journal
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
| العنوان: | Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients |
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| المؤلفون: | Decalf, Jérémie, Fernandes, Sandrine, Longman, Randy, Ahloulay, Mina, Audat, François, Lefrerre, François, Rice, Charles M., Pol, Stanislas, Albert, Matthew L. |
| المساهمون: | Immunobiologie des Cellules Dendritiques, Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Carcinogenèse Hépatique et Virologie Moléculaire, Institut National de la Santé et de la Recherche Médicale (INSERM), Rockefeller University New York, Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This work was supported in part by grants from La Ligue Nationale Contre le Cancer (J. Decalf and M.L. Albert), L'Agence Nationale de Recherches sur le SIDA et Hépatites, The European Young Investigator Awards Scheme, European Science Foundation, The Doris Duke Charitable Foundation, the Greenberg Medical Research Institute (C.M. Rice), and special support from Le Caisse de Retraite et de Prévoyance des Clercs et Employés de Notaires (M.L. Albert). |
| المصدر: | ISSN: 0022-1007. |
| بيانات النشر: | HAL CCSD Rockefeller University Press |
| سنة النشر: | 2007 |
| المجموعة: | Institut Pasteur: HAL |
| مصطلحات موضوعية: | [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | International audience ; Plasmacytoid dendritic cells (pDCs) are the professional type I interferon (IFN)-producing cells, and upon activation they traffic to lymph organs, where they bridge innate and adaptive immunity. Using multianalyte profiling (MAP), we have mapped the key chemokines and cytokines produced in response to pDC activation, taking into consideration the role of autocrine IFN, as well as paracrine effects on other innate cells (e.g., monocytes and conventional DCs). Interestingly, we identify four distinct cytokine/chemokine loops initiated by Toll-like receptor engagement. Finally, we applied this analytic approach to the study of pDC activity in chronic hepatitis C patients. Based on the activation state of pDCs in fresh blood, the lack of agonistic activity of infectious virions, the production of a broad array of cytokines/chemokines once stimulated, and the direct effects of pDCs on other PBMCs, we conclude that the pDCs from hepatitis C virus (HCV)-infected individuals are fully functional and are, indeed, a viable drug target. In sum, this study provides insight into the use of MAP technology for characterizing cytokine networks, and highlights how a rare cell type integrates the activation of other inflammatory cells. Furthermore, this work will help evaluate the therapeutic application of pDC agonists in diseases such as chronic HCV infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/17893202; pasteur-01402312; https://pasteur.hal.science/pasteur-01402312; https://pasteur.hal.science/pasteur-01402312/document; https://pasteur.hal.science/pasteur-01402312/file/2423-full.pdf; PUBMED: 17893202; PUBMEDCENTRAL: PMC2118448 |
| DOI: | 10.1084/jem.20070814 |
| الاتاحة: | https://pasteur.hal.science/pasteur-01402312 https://pasteur.hal.science/pasteur-01402312/document https://pasteur.hal.science/pasteur-01402312/file/2423-full.pdf https://doi.org/10.1084/jem.20070814 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.224C5B81 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20070814 |
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