Academic Journal
Insights on metabolic reprogramming and its therapeutic potential in acute leukemia
| العنوان: | Insights on metabolic reprogramming and its therapeutic potential in acute leukemia |
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| المؤلفون: | Di Martino L., Tosello V., Peroni E., Piovan E. |
| المساهمون: | Di Martino, L., Tosello, V., Peroni, E., Piovan, E. |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Acute leukemia, Metabolism, Targeted therapy |
| الوصف: | Acute leukemias, classified as acute myeloid leukemia and acute lymphoblastic leukemia, represent the most prevalent hematologic tumors in adolescent and young adults. In recent years, new challenges have emerged in order to improve the clinical effectiveness of therapies already in use and reduce their side effects. In particular, in this scenario, metabolic reprogramming plays a key role in tumorigenesis and prognosis, and it contributes to the treatment outcome of acute leukemia. This review summarizes the latest findings regarding the most relevant metabolic pathways contributing to the continuous growth, redox homeostasis, and drug resistance of leukemia cells. We describe the main metabolic deregulations in acute leukemia and evidence vulnerabilities that could be exploited for targeted therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34445444; info:eu-repo/semantics/altIdentifier/wos/WOS:000690485900001; volume:22; issue:16; firstpage:8738; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11577/3398919 |
| DOI: | 10.3390/ijms22168738 |
| الاتاحة: | http://hdl.handle.net/11577/3398919 https://doi.org/10.3390/ijms22168738 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.223533E5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms22168738 |
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