Academic Journal
Post-Translational Modifications to Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction
| العنوان: | Post-Translational Modifications to Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction |
|---|---|
| المؤلفون: | Charlie Boutin, Camille Clément, Jean Rivoal |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 18, p 9845 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | post-translational modification, cysteine, regulation, signal transduction, metabolism, thiol, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Cys is one of the least abundant amino acids in proteins. However, it is often highly conserved and is usually found in important structural and functional regions of proteins. Its unique chemical properties allow it to undergo several post-translational modifications, many of which are mediated by reactive oxygen, nitrogen, sulfur, or carbonyl species. Thus, in addition to their role in catalysis, protein stability, and metal binding, Cys residues are crucial for the redox regulation of metabolism and signal transduction. In this review, we discuss Cys post-translational modifications (PTMs) and their role in plant metabolism and signal transduction. These modifications include the oxidation of the thiol group ( S -sulfenylation, S -sulfinylation and S -sulfonylation), the formation of disulfide bridges, S -glutathionylation, persulfidation, S -cyanylation S -nitrosation, S -carbonylation, S -acylation, prenylation, CoAlation, and the formation of thiohemiacetal. For each of these PTMs, we discuss the origin of the modifier, the mechanisms involved in PTM, and their reversibility. Examples of the involvement of Cys PTMs in the modulation of protein structure, function, stability, and localization are presented to highlight their importance in the regulation of plant metabolic and signaling pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://www.mdpi.com/1422-0067/25/18/9845; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/a94a8fa6f0f1431ab5454619383ca45a |
| DOI: | 10.3390/ijms25189845 |
| الاتاحة: | https://doi.org/10.3390/ijms25189845 https://doaj.org/article/a94a8fa6f0f1431ab5454619383ca45a |
| رقم الانضمام: | edsbas.22167A58 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms25189845 |
|---|