Academic Journal
Targeted doxorubicin delivery and release within breast cancer environment using PEGylated chitosan nanoparticles labeled with monoclonal antibodies
| العنوان: | Targeted doxorubicin delivery and release within breast cancer environment using PEGylated chitosan nanoparticles labeled with monoclonal antibodies |
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| المؤلفون: | Helmi, Omar, Elshishiny, Fatma, Mamdouh, Wael |
| المصدر: | Faculty Journal Articles |
| بيانات النشر: | AUC Knowledge Fountain |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Anti-HER2 monoclonal antibody, Doxorubicin targeted drug delivery, PEGylated chitosan nanoparticle |
| الوصف: | Breast cancer has been one of the top chronic and life-threatening diseases worldwide. Nano-drug therapeutic systems have proved their efficacy as a selective treatment compared to the traditional ones that are associated with serious adverse effects. Here, biodegradable chitosan nanoparticles (CSNPs) were synthesized to provide selective and sustained release of doxorubicin (DOX) within the breast tumor microenvironment. CSNPs surface was modified using Polyethylene glycol (PEG) to enhance their blood circulation timing. To provide high drug selectivity, CSNPs functionalized with two different types of breast cancer-specific monoclonal antibodies (mAb); anti-human mammaglobin (Anti-hMAM) and anti-human epidermal growth factor (Anti-HER2). Anti-hMAM PEGylated DOX loaded CSNPs and Anti-HER2 PEGylated DOX loaded CSNPs nano-formulations were the most cytotoxic against MCF-7 cancer cells than L-929 normal cells compared to free DOX. Finally, we believe that dose-dependent system toxicity of freely ingested DOX can be managed with such targeted nano-formulated drug delivery platforms. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| Relation: | https://fount.aucegypt.edu/faculty_journal_articles/2301 |
| DOI: | 10.1016/j.ijbiomac.2021.06.014 |
| الاتاحة: | https://fount.aucegypt.edu/faculty_journal_articles/2301 https://doi.org/10.1016/j.ijbiomac.2021.06.014 |
| رقم الانضمام: | edsbas.2203084C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijbiomac.2021.06.014 |
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