Academic Journal
Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest
| العنوان: | Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest |
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| المؤلفون: | Vítovcová, Barbora, Skarková, Veronika, Havelek, Radim, Soukup, Jiří, Pande, Ananya, Caltová, Kateřina, Rudolf, Emil |
| المصدر: | Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Glioblastoma multiforme (GBM) belongs to most aggressive and invasive primary brain tumor in adults whose prognosis and survival remains poor. Potential new treatment modalities include targeting the cytoskeleton. In our study, we demonstrated that repurposed drug flubendazole (FLU) significantly inhibits proliferation and survival of GBM cells. FLU exerted its effect by affecting microtubule structure and our results also suggest that FLU influences tubulins expression to a certain degree. Moreover, FLU effects decreased activation of STAT3 and also partially inhibited its expression, leading to upregulation of p53 signaling pathway and subsequent cell cycle arrest at G2/M phase as well as caspase-dependent cell death in GBM cells. These results suggest FLU as a promising agent to be used in GBM treatment and prompting further testing of its effects on GBM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-023-33047-9 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-023-33047-9 https://www.nature.com/articles/s41598-023-33047-9.pdf https://www.nature.com/articles/s41598-023-33047-9 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.21E89BF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-023-33047-9 |
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