Academic Journal
A Higher CD105-Assessed Microvessel Densityand Worse Prognosis in Elderly PatientsWith Laryngeal Carcinoma
| العنوان: | A Higher CD105-Assessed Microvessel Densityand Worse Prognosis in Elderly PatientsWith Laryngeal Carcinoma |
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| المؤلفون: | MARIONI, GINO, STAFFIERI, ALBERTO, MANZATO, ENZO, BLANDAMURA, STELLA, RALLI G, LIONELLO M, GIACOMELLI L, PROSENIKLIEV V, MARCHESE RAGONA R, BUSNARDO B, BOLLETTA F |
| المساهمون: | Marioni, Gino, Staffieri, Alberto, Manzato, Enzo, Ralli, G, Lionello, M, Giacomelli, L, Prosenikliev, V, MARCHESE RAGONA, R, Busnardo, B, Bolletta, F, Blandamura, Stella |
| سنة النشر: | 2011 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| الوصف: | Objectives: To ascertain the prognostic role of endoglin (CD105)-assessed microvessel density (MVD) in patients older than 65 years with laryngeal squamous cell carcinoma (LSCC), and whether thisMVDdiffered in the elderly patients from younger adult controls. Design: Retrospective clinicopathologic investigation. Setting: Academic tertiary referral center. Patients: Fifty-seven consecutive elderly patients with LSCC and 19 younger adult controls. Main Outcome Measure: Image analysis of immunohistochemical reactions. Results: In LSCCs in elderly patients, N stage correlated with a shorter disease-free survival (DFS) (P.001). A higher CD105-assessed MVD was associated with disease recurrence (P=.006). The DFS was shorter in elderly patients whose CD105 expression was greater than 9.6% than in patients whose CD105 expression was 9.6% or less (P=.001). Among the elderly patients with tumors staged as N0, a higher CD105-assessed MVD correlated with disease recurrence (P=.006) and a shorter DFS (P=.001). CD105-assessed MVD in LSCC occurring in elderly patients did not differ from the situation observed in younger adult controls (P=.74). Conclusions: In LSCC occurring in elderly patients, CD105-assessed MVD may be a useful N-stage independent, angiogenic prognostic marker for pinpointing: (1) patients at higher risk of disease recurrence; and (2) patients with N0 tumors at higher risk of early recurrence, who may benefit from more aggressive therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/21339405; info:eu-repo/semantics/altIdentifier/wos/WOS:000287536900012; volume:137(2); firstpage:175; lastpage:180; numberofpages:6; journal:ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY; http://hdl.handle.net/11577/2425831; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79952026683 |
| DOI: | 10.1001/archoto.2010.244 |
| الاتاحة: | http://hdl.handle.net/11577/2425831 https://doi.org/10.1001/archoto.2010.244 |
| رقم الانضمام: | edsbas.21D261A2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/archoto.2010.244 |
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