Academic Journal
Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children
| العنوان: | Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children |
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| المؤلفون: | Midya, Vishal, Colicino, Elena, Conti, David, V, Berhane, Kiros, Garcia, Erika, Stratakis, Nikos, Andrusaityte, Sandra, Basagaña, Xavier, Casas, Maribel, Fossati, Serena, Gražulevičienė, Regina, Haug, Småstuen, Heude, Barbara, Maitre, Léa, Mceachan, Rosemary, Papadopoulou, Eleni, Roumeliotaki, Theano, Philippat, Claire, Thomsen, Cathrine, Urquiza, Jose, Vafeiadi, Marina, Varo, Nerea, Vos, Miriam, B, Wright, John, Mcconnell, Rob, Vrijheid, Martine, Chatzi, Lida, Valvi, Damaskini |
| المساهمون: | Icahn School of Medicine at Mount Sinai New York (MSSM), Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, Department of Biostatistics, Columbia University, New York City, New York, Department of Environmental Sciences, Vytautas Magnus University, Kaunas, Lithuania, Instituto de Salud Global - Institute For Global Health Barcelona (ISGlobal), Universitat Pompeu Fabra Barcelona (UPF), Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Madrid, Spain, Centre for Research in Epidemiology and Statistics, Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS (National Health Service) Foundation Trust, Bradford, United Kingdom, Norwegian Institute of Public Health Oslo (NIPH), Department of Social Medicine, University of Crete, Heraklion, Greece, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, Grenoble Alpes University, INSERM, Centre National de la Recherche Scientifique, La Tronche, France, Clinical Biochemistry Department, Clínica Universidad de Navarra, Pamplona, Spain, Department of Pediatrics, Emory University, Atlanta, Georgia |
| المصدر: | EISSN: 2574-3805 ; JAMA Network Open ; https://hal.science/hal-04662281 ; JAMA Network Open, 2022, 5 (7), pp.e2220176. ⟨10.1001/jamanetworkopen.2022.20176⟩ |
| بيانات النشر: | CCSD American Medical Association |
| سنة النشر: | 2022 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | Midya Conti Berhane Basagaña Papadopoulou Valvi Heude McEachan Thomsen Vrijheid Chatzi Valvi Andrusaityte Casas Gražulevičienė Thomsen Urquiza Chatzi Valvi Colicino McEachan Vafeiadi Wright McConnell Vrijheid Chatzi Valvi, Midya, Conti, Berhane, Basagaña, Papadopoulou, Valvi Heude, McEachan, Thomsen, Vrijheid, Chatzi, Valvi Andrusaityte, Casas, Gražulevičienė, Urquiza, Valvi Colicino, Vafeiadi, Wright, McConnell, Valvi, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; Importance: Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human evidence is scarce, and previous studies have not considered potential EDC-mixture effects. Furthermore, the association between prenatal EDC exposure and hepatocellular apoptosis in children has not been studied previously.Objective: To investigate associations of prenatal exposure to EDC mixtures with liver injury risk and hepatocellular apoptosis in childhood.Design, setting, and participants: This prospective cohort study used data collected from April 1, 2003, to February 26, 2016, from mother-child pairs from the Human Early-Life Exposome project, a collaborative network of 6 ongoing, population-based prospective birth cohort studies from 6 European countries (France, Greece, Lithuania, Norway, Spain, and the UK). Data were analyzed from April 1, 2021, to January 31, 2022.Exposures: Three organochlorine pesticides, 5 polychlorinated biphenyls, 2 polybrominated diphenyl ethers (PBDEs), 3 phenols, 4 parabens, 10 phthalates, 4 organophosphate pesticides, 5 perfluoroalkyl substances, and 9 metals.Main outcomes and measures: Child serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and CK-18 were measured at 6 to 11 years of age. Risk for liver injury was defined as having ALT, AST, and/or GGT levels above the 90th percentile. Associations of liver injury or cytokeratin 18 (CK-18) levels with each chemical group among the 45 EDCs measured in maternal blood or urine samples collected in pregnancy were estimated using 2 complimentary exposure-mixture methods: bayesian weighted quantile sum (BWQS) and bayesian kernel machine regression.Results: The study included 1108 mothers (mean [SD] age at birth, 31.0 [4.7] years) and their singleton children (mean [SD] age at liver assessment, 8.2 [1.6] years; 598 [54.0%] boys). Results of the BWQS method indicated increased odds of liver injury per ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1001/jamanetworkopen.2022.20176 |
| الاتاحة: | https://hal.science/hal-04662281 https://hal.science/hal-04662281v1/document https://hal.science/hal-04662281v1/file/Midya_JAMA_2022.pdf https://doi.org/10.1001/jamanetworkopen.2022.20176 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.21BAA5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamanetworkopen.2022.20176 |
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