Academic Journal
Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: A pooled analysis of six European cohorts within the ELAPSE project.
| العنوان: | Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: A pooled analysis of six European cohorts within the ELAPSE project. |
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| المؤلفون: | Wolf, K., Hoffmann, B., Andersen, Z.J., Atkinson, R.W., Bauwelinck, M., Bellander, T., Brandt, J., Brunekreef, B., Cesaroni, G., Chen, J., de Faire, U., de Hoogh, K., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hvidtfeldt, U.A., Janssen, N.A.H., Jørgensen, J.T., Katsouyanni, K., Ketzel, M., Klompmaker, J.O., Lager, A., Liu, S., MacDonald, C.J., Magnusson, P.K.E., Mehta, A.J., Nagel, G., Oftedal, B., Pedersen, N.L., Pershagen, G., Raaschou-Nielsen, O., Renzi, M., Rizzuto, D., Rodopoulou, S., Samoli, E., van der Schouw, Y.T., Schramm, S., Schwarze, P., Sigsgaard, T., Sørensen, M., Stafoggia, M., Strak, M., Tjønneland, A., Verschuren, W.M.M., Vienneau, D., Weinmayr, G., Hoek, G., Peters, A., Ljungman, P.L.S. |
| المصدر: | Lancet Planet Health 5, e620-e632 (2021) |
| سنة النشر: | 2021 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| الوصف: | BACKGROUND: Long-term exposure to outdoor air pollution increases the risk of cardiovascular disease, but evidence is unclear on the health effects of exposure to pollutant concentrations lower than current EU and US standards and WHO guideline limits. Within the multicentre study Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we investigated the associations of long-term exposures to fine particulate matter (PM2·5), nitrogen dioxide (NO2), black carbon, and warm-season ozone (O3) with the incidence of stroke and acute coronary heart disease. METHODS: We did a pooled analysis of individual data from six population-based cohort studies within ELAPSE, from Sweden, Denmark, the Netherlands, and Germany (recruited 1992-2004), and harmonised individual and area-level variables between cohorts. Participants (all adults) were followed up until migration from the study area, death, or incident stroke or coronary heart disease, or end of follow-up (2011-15). Mean 2010 air pollution concentrations from centrally developed European-wide land use regression models were assigned to participants' baseline residential addresses. We used Cox proportional hazards models with increasing levels of covariate adjustment to investigate the association of air pollution exposure with incidence of stroke and coronary heart disease. We assessed the shape of the concentration-response function and did subset analyses of participants living at pollutant concentrations lower than predefined values. FINDINGS: From the pooled ELAPSE cohorts, data on 137 148 participants were analysed in our fully adjusted model. During a median follow-up of 17·2 years (IQR 13·8-19·5), we observed 6950 incident events of stroke and 10 071 incident events of coronary heart disease. Incidence of stroke was associated with PM2·5 (hazard ratio 1·10 [95% CI 1·01-1·21] per 5 μg/m3 increase), NO2 (1·08 [1·04-1·12] per 10 μg/m3 increase), and black carbon (1·06 [1·02-1·10] per 0·5 10-5/m increase), whereas coronary heart disease incidence was only ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34508683; info:eu-repo/semantics/altIdentifier/wos/WOS:000696927000008; info:eu-repo/semantics/altIdentifier/isbn/2542-5196; info:eu-repo/semant |
| DOI: | 10.1016/S2542-5196(21)00195-9 |
| الاتاحة: | https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=63064 https://doi.org/10.1016/S2542-5196(21)00195-9 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.2197B5AD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S2542-5196(21)00195-9 |
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