Academic Journal
A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions
| العنوان: | A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions |
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| المؤلفون: | Eisler, Stephan A, Curado, Filipa, Link, Gisela, Schulz, Sarah, Noack, Melanie, Steinke, Maren, Olayioye, Monilola A, Hausser, Angelika |
| المساهمون: | Deutsche Krebshilfe, Deutsche Forschungsgemeinschaft, Volkswagen Foundation |
| المصدر: | eLife ; volume 7 ; ISSN 2050-084X |
| بيانات النشر: | eLife Sciences Publications, Ltd |
| سنة النشر: | 2018 |
| المجموعة: | eLife (E-Journal - via CrossRef) |
| الوصف: | Protein kinase D (PKD) is a family of serine/threonine kinases that is required for the structural integrity and function of the Golgi complex. Despite its importance in the regulation of Golgi function, the molecular mechanisms regulating PKD activity are still incompletely understood. Using the genetically encoded PKD activity reporter G-PKDrep we now uncover a Rho signaling network comprising GEF-H1, the RhoGAP DLC3, and the Rho effector PLCε that regulate the activation of PKD at trans-Golgi membranes. We further show that this molecular network coordinates the formation of TGN-derived Rab6-positive transport carriers delivering cargo for localized exocytosis at focal adhesions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7554/elife.35907 |
| الاتاحة: | http://dx.doi.org/10.7554/elife.35907 https://cdn.elifesciences.org/articles/35907/elife-35907-v2.pdf https://cdn.elifesciences.org/articles/35907/elife-35907-v2.xml https://elifesciences.org/articles/35907 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.21652D60 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/elife.35907 |
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