Academic Journal

Semicontinuous Lixiviation Process for Compound Extraction from Cannabis sativa grown in Colombia ; Proceso semicontinuo de lixiviación para la extracción de compuestos a partir de Cannabis sativa cultivado en Colombia

التفاصيل البيبلوغرافية
العنوان: Semicontinuous Lixiviation Process for Compound Extraction from Cannabis sativa grown in Colombia ; Proceso semicontinuo de lixiviación para la extracción de compuestos a partir de Cannabis sativa cultivado en Colombia
المؤلفون: Buitrago Suescún, Oscar Yecid, Santaella Serrano, Miguel Augusto
المصدر: Ingeniería e Investigación; Vol. 42 No. 2 (2022); e91616 ; Ingeniería e Investigación; Vol. 42 Núm. 2 (2022); e91616 ; 2248-8723 ; 0120-5609
بيانات النشر: Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ingeniería
سنة النشر: 2021
المجموعة: Universidad Nacional de Colombia: Portal de Revistas UN
مصطلحات موضوعية: cannabis sativa, lixiviation, agroindustry, semicontinuos process, solvent extraction, chemical engineering, sustainable production
الوصف: The extraction of compounds present in Cannabis sativa biomass from Colombian crops was studied using a semi-continuous lixiviation process. To this effect, three extraction stages were implemented, in which successive transfers were carried out at fixed times, seeking to emulate a continuous countercurrent process. In this way, the intention is to provide the Colombian agroindustry with an extraction method that is efficient and requires a lower initial investment than other techniques such as supercritical fluid extraction. Absolute ethanol was used as solvent, and constant temperature and stirring speed were applied. The obtained results indicate that, once the process is stabilized, extracted mass percentages (with respect to the total mass on a dry basis) of 10,5% at 40 °C and 9,5% at 19 °C are achieved, which are competitive compared to the 11,07% achieved through Soxhlet extraction. Besides, the proposed process is clearly a better alternative than a single-stage extraction method, through which it was possible to extract 5% of the mass. Five cannabinoids were identified in the obtained extract, and, with the proposed process, it was possible to extract 66% of cannabidiol present in the original biomass. ; Se estudió la extracción de compuestos presentes en la biomasa de Cannabis sativa de cultivos colombianos mediante un proceso de lixiviación semicontinuo. Para tal fin se implementaron tres etapas de extracción, en las cuales se realizaron transvases sucesivos en tiempos determinados, buscando emular un proceso continuo a contracorriente. De esta forma se pretende proporcionar a la agroindustria colombiana un método de extracción que sea eficiente y requiera una inversión inicial más baja que otras alternativas tales como la extracción con fluidos supercríticos. Se empleó etanol absoluto como solvente y se aplicaron temperaturas y velocidades de agitación constantes. Los resultados obtenidos muestran que, una vez estabilizado el proceso, se logran porcentajes de masa extraída (con respecto a la masa ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf; text/xml
اللغة: English
Relation: https://revistas.unal.edu.co/index.php/ingeinv/article/view/91616/82207; https://revistas.unal.edu.co/index.php/ingeinv/article/view/91616/83928; Amaducci, S., Zatta, A., Pelatti, F., and Venturi, G. (2008). Influence of agronomic factors on yield and quality of hemp (Cannabis sativa L.) fiber and implication for an innovative production system. Field Crops Research, 107(2), 161-169. https://doi.org/10.1016/j.fcr.2008.02.002; Attard, T. M., Bainier, C., Reinaud, M., Lanot, A., McQueen-Mason, S. J., and Hunt, A. J. (2018). Utilization of supercritical fluids for the effective extraction of waxes and Cannabidiol (CBD) from hemp wastes. Industrial Crops and Products, 112, 38-46. https://doi.org/10.1016/j.indcrop.2017.10.045; Baldino, L., Reverchon, E., and Della, G. (2017). An optimized process for SC-CO2 extraction of antimalarial compounds from Artemisia annua L. The Journal of Supercritical Fluids, 128, 89-93. https://doi.org/10.1016/j.supflu.2017.05.018; Baldino, L., Scognamiglio, M., and Reverchon, E. (2020). Super-critical fluid technologies applied to the extraction of compounds of industrial interest from Cannabis sativa L. and to their pharmaceutical formulations: A review. Journal of Supercritical Fluids, 165, 104960. https://doi.org/10.1016/j.supflu.2020.104960; Booth, J. K. and Bohlmann, J. (2019). Terpenes in Cannabis sativa – From plant genome to humans. Plant Science, 284, 67-72. https://doi.org/10.1016/j.plantsci.2019.03.022; Da Porto, C., Voinovich, D., Decorti, D., and Natolino, A. (2012). Response surface optimization of hemp seed (Cannabis sativa L.) oil yield and oxidation stability by supercritical carbon dioxide extraction. Journal of Supercritical Fluids, 68, 45-51. https://doi.org/10.1016/j.supflu.2012.04.008; da Silva, R. P. F. F., Rocha-Santos, T. A. P., and Duarte, A. C. (2016). Supercritical fluid extraction of bioactive compounds. TrAC - Trends in Analytical Chemistry, 76, 40-51. https://doi.org/10.1016/j.trac.2015.11.013; Delgado-Povedano, M. M., Sánchez-Carnerero Callado, C., Priego-Capote, F., and Ferreiro-Vera, C. (2019). Untargeted characterization of extracts from Cannabis sativa L. cultivars by gas and liquid chromatography coupled to mass spec-trometry in high resolution mode. Talanta, 208, 120384. https://doi.org/10.1016/j.talanta.2019.120384; Elkins, A. C., Deseo, M. A., Rochfort, S., Ezernieks, V., and Span-genberg, G. (2019). Development of a validated method for the qualitative and quantitative analysis of cannabinoids in plant biomass and medicinal cannabis resin extracts obtained by supercritical fluid extraction. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1109, 76-83. https://doi.org/10.1016/j.jchromb.2019.01.027; Fiorini, D., Molle, A., Nabissi, M., Santini, G., Benelli, G., and Maggi, F. (2019). Valorizing industrial hemp (Cannabis sativa L.) by-products: Cannabidiol enrichment in the inflorescence essential oil optimizing sample pre-treatment prior to distillation. Industrial Crops and Products, 128, 581-589. https://doi.org/10.1016/j.indcrop.2018.10.045; Gallo-Molina, A. C., Castro-Vargas, H. I., Garzón-Méndez, W. F., Martínez-Ramírez, J. A., Rivera-Monroy, Z. J., King, J. W., and Parada-Alfonso, F. (2019). Extraction, isolation and purification of tetrahydrocannabinol from the Cannabis sativa L. plant using supercritical fluid extraction and solid phase extraction. Journal of Supercritical Fluids, 146, 208–216. https://doi.org/10.1016/j.supflu.2019.01.020; Koltai, H. and Namdar, D. (2020). Cannabis Phytomolecule “Entourage”: From Domestication to Medical Use. Trends in Plant Science, 25(10), 976-984. https://doi.org/10.1016/j.tplants.2020.04.007; Marzorati, S., Friscione, D., Picchi, E., and Verotta, L. (2020). Cannabidiol from inflorescences of Cannabis sativa L.: Green extraction and purification processes. Industrial Crops and Products, 155, 112816. https://doi.org/10.1016/j.indcrop.2020.112816; Moreno, T., Montanes, F., Tallon, S. J., Fenton, T., and King, J. W. (2020). Extraction of cannabinoids from hemp (Cannabis sativa L.) using high-pressure solvents: An overview of different processing options. Journal of Supercritical Fluids, 161, 104850. https://doi.org/10.1016/j.supflu.2020.104850; Mudge, E. M., Murch, S. J., and Brown, P. N. (2017). Leaner and greener analysis of cannabinoids. Analytical and Bioanalytical Chemistry, 409(12), 3153-3163. https://doi.org/10.1007/s00216-017-0256-3; Namdar, D., Mazuz, M., Ion, A., and Koltai, H. (2018). Variation in the compositions of cannabinoid and terpenoids in Cannabis sativa derived from inflorescence position along the stem and extraction methods. Industrial Crops and Products, 113, 376-382. https://doi.org/10.1016/j.indcrop.2018.01.060; Qamar, S., Torres, Y. J. M., Parekh, H. S., and Falconer, J. R. (2021). Extraction of medicinal cannabinoids through supercritical carbon dioxide technologies: A review. Journal of Chromatography B, 1167, 122581. https://doi.org/10.1016/j.jchromb.2021.122581; Ribeiro Grijó, D., Vieitez Osorio, I. A., and Cardozo-Filho, L. (2019). Supercritical Extraction Strategies Using CO2 and Ethanol to Obtain Cannabinoid Compounds from Cannabis Hybrid Flowers. Journal of CO2 Utilization, 30, 241-248. https://doi.org/10.1016/j.jcou.2018.12.014; Rovetto, L. J. and Aieta, N. V. (2017). Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L. Journal of Supercritical Fluids, 129, 16-27. https://doi.org/10.1016/j.supflu.2017.03.014; Ternelli, M., Brighenti, V., Anceschi, L., Poto, M., Bertelli, D., Licata, M., and Pellati, F. (2020). Innovative methods for the preparation of medical Cannabis oils with a high content of both cannabinoids and terpenes. Journal of Pharmaceutical and Biomedical Analysis, 186, 113296. https://doi.org/10.1016/j.jpba.2020.113296; https://revistas.unal.edu.co/index.php/ingeinv/article/view/91616
الاتاحة: https://revistas.unal.edu.co/index.php/ingeinv/article/view/91616
Rights: Derechos de autor 2021 Oscar Yecid Buitrago Suescún, Miguel Augusto Santaella Serrano ; https://creativecommons.org/licenses/by/4.0
رقم الانضمام: edsbas.2152717
قاعدة البيانات: BASE