Academic Journal
Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis
| العنوان: | Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis |
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| المؤلفون: | Matta, B., Barnes, B. J. |
| المصدر: | Journal Articles |
| بيانات النشر: | Donald and Barbara Zucker School of Medicine Academic Works |
| سنة النشر: | 2019 |
| المجموعة: | Hofstra Northwell Academic Works (Hofstra Northwell School of Medicine) |
| مصطلحات موضوعية: | Medical Molecular Biology |
| الوصف: | © 2019 Elsevier Ltd Systemic lupus erythematosus (SLE) is a complex autoimmune disease which affects multiple organs. The type I interferon (IFN) gene signature and circulating autoantibodies are hallmarks of SLE. Plasmacytoid dendritic cells (pDCs) are considered the main producers of type I IFN and production is modulated by multiple other immune cell types. In SLE, essentially every immune cell type is dysregulated and aberrant deregulation is thought to be due, in part, to direct or indirect exposure to IFN. Genetic variants within or around the transcription factor interferon regulatory factor 5 (IRF5) associate with SLE risk. Elevated IFNα activity was detected in the sera of SLE patients carrying IRF5 risk polymorphisms who were positive for either anti-RNA binding protein (anti-RBP) or anti-double-stranded DNA (anti-dsDNA) autoantibodies. Neutrophils are also an important source of type I IFNs and are found in abundance in human blood. Neutrophil extracellular traps (NETs) are considered a potential source of antigenic trigger in SLE that can lead to type I IFN gene induction, as well as increased autoantibody production. In this review, we will focus on immune cell types that produce type I IFNs and/or are affected by type I IFN in SLE. In addition, we will discuss potential inducers of endogenous type I IFN production in SLE. Last, we will postulate how the different immune cell populations may be affected by an IRF5-SLE risk haplotype. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| Relation: | https://academicworks.medicine.hofstra.edu/publications/5297; https://my.hofstra.edu/hofapps/applications/ezproxy/indexMed.jsp?db_proxy=m&&db_url=www.sciencedirect.com/science/article/abs/pii/S1043466619301413 |
| DOI: | 10.1016/j.cyto.2019.05.018 |
| الاتاحة: | https://academicworks.medicine.hofstra.edu/publications/5297 https://my.hofstra.edu/hofapps/applications/ezproxy/indexMed.jsp?db_proxy=m&&db_url=www.sciencedirect.com/science/article/abs/pii/S1043466619301413 |
| رقم الانضمام: | edsbas.214BBCA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cyto.2019.05.018 |
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