Academic Journal
DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase.
| العنوان: | DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase. |
|---|---|
| المؤلفون: | Amand, Mathieu, Erpicum, Charlotte, Bajou, Khalid, Cerignoli, Fabio, Blacher, Silvia, Martin, Maud, Dequiedt, Franck, Drion, Pierre, Singh, Pratibha, Zurashvili, Tinatin, Vandereyken, Maud, Musumeci, Lucia, Mustelin, Tomas, Moutschen, Michel, Gilles, Christine, Noël, Agnès, Rahmouni, Souad |
| المصدر: | Molecular cancer, 13 |
| سنة النشر: | 2014 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, Animals, Carcinoma, Lewis Lung -- genetics -- metabolism -- pathology, Cell Movement, Cervix Uteri -- blood supply -- metabolism -- pathology, Collagen, Drug Combinations, Dual Specificity Phosphatase 3 -- genetics -- metabolism, ErbB Receptors -- genetics -- metabolism, Extracellular Signal-Regulated MAP Kinases -- genetics -- metabolism, Female, Fibroblast Growth Factors, Gene Expression Regulation, Human Umbilical Vein Endothelial Cells -- cytology -- metabolism, Humans, Laminin, MAP Kinase Kinase 4 -- genetics -- metabolism, Mice, Knockout, Neovascularization, Pathologic -- prevention & control, Physiologic -- genetics, Phosphorylation, Protein Kinase C -- genetics -- metabolism, Proteoglycans, Signal Transduction |
| الوصف: | DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP3 is a negative regulator of ERK and JNK pathways in several cell lines. On the other hand, DUSP3 is implicated in human cancer. It has been alternatively described as having tumor suppressive and oncogenic properties. Thus, the available data suggest that DUSP3 plays complex and contradictory roles in tumorigenesis that could be cell type-dependent. Since most of these studies were performed using recombinant proteins or in cell-transfection based assays, the physiological function of DUSP3 has remained elusive. ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| Relation: | uri/info:doi/10.1186/1476-4598-13-108; uri/info:pii/1476-4598-13-108; uri/info:pmid/24886454; uri/info:pmcid/PMC4038117; https://dipot.ulb.ac.be/dspace/bitstream/2013/324563/1/doi_308207.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/324563 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/324563 https://dipot.ulb.ac.be/dspace/bitstream/2013/324563/1/doi_308207.pdf |
| رقم الانضمام: | edsbas.21078874 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |