Academic Journal
Risk of Cardiovascular Conditions in Patients with Chronic Hypoparathyroidism:A Retrospective Cohort Study
| العنوان: | Risk of Cardiovascular Conditions in Patients with Chronic Hypoparathyroidism:A Retrospective Cohort Study |
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| المؤلفون: | Gosmanova, Elvira O, Chen, Kristina, Ketteler, Markus, Rejnmark, Lars, Mu, Fan, Swallow, Elyse, Briggs, Allison, Sherry, Nicole, Kaul, Sanjiv |
| المصدر: | Gosmanova , E O , Chen , K , Ketteler , M , Rejnmark , L , Mu , F , Swallow , E , Briggs , A , Sherry , N & Kaul , S 2021 , ' Risk of Cardiovascular Conditions in Patients with Chronic Hypoparathyroidism : A Retrospective Cohort Study ' , Advances in Therapy , vol. 38 , no. 8 , pp. 4246-4257 . https://doi.org/10.1007/s12325-021-01787-7 |
| سنة النشر: | 2021 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | Arrhythmia, Cardiovascular disease, Chronic hypoparathyroidism, Retrospective cohort study |
| الوصف: | Introduction: In patients with chronic hypoparathyroidism disordered calcium homeostasis has been associated with risk of cardiovascular diseases, including cardiomyopathy, congestive heart failure, and arrhythmia; however, larger-scale studies are needed to examine these risks. This study evaluated the risk of cardiovascular conditions among patients with chronic hypoparathyroidism. Methods: Adults with and without chronic hypoparathyroidism were selected from a medical insurance claims database in the USA from January 2007 to June 2017, and were followed for up to 5 years. Associations between chronic hypoparathyroidism and incident atrial fibrillation (AF), tachyarrhythmia, myocardial infarction (MI), coronary artery disease (CAD), heart failure (HF), stroke, cerebrovascular disease, peripheral vascular disease (PVD), and a combined cardiovascular endpoint of cerebrovascular disease, CAD, HF, and PVD were compared between cohorts using Kaplan–Meier analyses and unadjusted and adjusted Cox proportional hazards models. Results: In 8097 patients with chronic hypoparathyroidism compared with 40,485 patients without, respectively, mean ± SD ages were 58.6 ± 16.3 and 47.3 ± 18.0 years, 76.2% and 54.4% were female, and 19.4% and 9.5% had the combination of cardiovascular findings at baseline. In adjusted analyses, patients with chronic hypoparathyroidism had significantly higher risk (adjusted hazard ratio and 95% confidence interval) of incident AF (1.72; 1.51–1.97), tachyarrhythmia (1.68; 1.32–2.14), MI (1.18; 1.01–1.38), CAD (1.39; 1.26–1.54), HF (1.64; 1.46–1.84), stroke (1.45; 1.31–1.62), cerebrovascular disease (1.48; 1.34–1.62), PVD (1.66; 1.51–1.81), and combined cardiovascular endpoint (1.63; 1.52–1.75), all P < 0.001 except P = 0.036 for MI, compared with patients without chronic hypoparathyroidism. Conclusions: This large retrospective cohort study showed that chronic hypoparathyroidism was associated with increased risk of incident cardiovascular conditions and arrhythmias. Results should be evaluated ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s12325-021-01787-7 |
| الاتاحة: | https://pure.au.dk/portal/da/publications/risk-of-cardiovascular-conditions-in-patients-with-chronic-hypoparathyroidism(5ae0c81a-f8de-4b68-98c2-ff2f717cf073).html https://doi.org/10.1007/s12325-021-01787-7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342323/ |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.21025828 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12325-021-01787-7 |
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