Academic Journal
Silent myocardial infarction fatty scars detected by coronary calcium score CT scan in diabetic patients without history of coronary heart disease
| العنوان: | Silent myocardial infarction fatty scars detected by coronary calcium score CT scan in diabetic patients without history of coronary heart disease |
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| المؤلفون: | Boccalini, Sara, Teulade, M., Paquet, E., Si-Mohamed, S., Rapallo, F., Moreau-Triby, C., Charrière, S., Mewton, N., Boussel, L., Bergerot, C., Douek, P., Moulin, P. |
| المساهمون: | Hôpital Louis Pradel CHU - HCL, Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli studi di Genova = University of Genoa (UniGe), Hôpital de la Croix-Rousse CHU - HCL |
| المصدر: | ISSN: 0938-7994. |
| بيانات النشر: | CCSD Springer Verlag |
| سنة النشر: | 2023 |
| المجموعة: | Institut National de la Recherche Agronomique: ProdINRA |
| مصطلحات موضوعية: | Myocardial infarction, Cardiac-gated imaging techniques, Coronary artery disease, Diabetes mellitus, Tomography, X-ray computed, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; OBJECTIVES: To evaluate the prevalence of intra-myocardial fatty scars (IMFS) most likely indicating previous silent myocardial infarction (SMI), as detected on coronary artery calcium (CAC) computed tomography (CT) scans in diabetic patients without history of coronary heart disease (CHD). METHODS: Diabetic patients screened for silent coronary insufficiency in a tertiary-care, university hospital between Jan-2015 and Dec-2016 were categorized according to their CAC score in two groups comprising 242 patients with CACS = 0 and 145 patients with CACS ≥ 300. CAC-CT scans were retrospectively evaluated for subendorcardial and transmural IMFS of the left ventricle. Adipose remodeling, patients' characteristics, cardiovascular risk factors and metabolic profile were compared between groups. RESULTS: Eighty-three (21%) patients with IMFS were identified, 55 (37.9%) in the group CACS ≥ 300 and 28 (11.6%) in the CACS = 0 (OR = 4.67; 95% CI = 2.78-7.84; p \textless 0.001). Total and average surface of IMFS and their number per patient were similar in both groups (p = 0.55; p = 0.29; p = 0.61, respectively). In the group CACS ≥ 300, patients with IMFS were older (p = 0.03) and had longer-lasting diabetes (p = 0.04). Patients with IMFS were older and had longer history of diabetes, reduced glomerular filtration rate, more coronary calcifications (all p \textless 0.05), and higher prevalence of carotid plaques (OR = 3.03; 95% CI = 1.43-6.39, p = 0.004). After correction for other variables, only a CACS ≥ 300 (OR = 5.12; 95% CI = 2.66-9.85; p \textless 0.001) was associated with an increased risk of having IMFS. CONCLUSIONS: In diabetic patients without known CHD, IMFSs were found in patients without coronary calcifications, although not as frequently as in patients with heavily calcified coronary arteries. It remains to be established if this marker translates in an upwards cardiovascular risk restratification especially in diabetic patients with CACS = 0. CLINICAL RELEVANCE STATEMENT: In diabetic ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37530810; PUBMED: 37530810; PUBMEDCENTRAL: PMC10791785 |
| DOI: | 10.1007/s00330-023-09940-2 |
| الاتاحة: | https://inserm.hal.science/inserm-04432144 https://inserm.hal.science/inserm-04432144v1/document https://inserm.hal.science/inserm-04432144v1/file/main.pdf https://doi.org/10.1007/s00330-023-09940-2 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.20FCF18 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00330-023-09940-2 |
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