Academic Journal
Preparative resolution of the enantiomers of Tert‐leucine derivatives by simulated moving bed chromatography
| العنوان: | Preparative resolution of the enantiomers of Tert‐leucine derivatives by simulated moving bed chromatography |
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| المؤلفون: | Francotte, Eric, Leutert, Thomas, La Vecchia, Luiggi, Ossola, Flavio, Richert, Paul, Schmidt, Alfred |
| المصدر: | Chirality ; volume 14, issue 4, page 313-317 ; ISSN 0899-0042 1520-636X |
| بيانات النشر: | Wiley |
| سنة النشر: | 2002 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The enantiomers of two different derivatives of tert ‐leucine were separated by continuous chromatography on chiral stationary phases applying the simulated moving bed technique. About 1 kg of racemic N ‐carbobenzoxy‐ tert ‐leucine was resolved on the cellulose‐based phase Chiralcel OD using a mixture of heptane/ethanol and 0.1% of trifluoroacetic acid modifier as the mobile phase, while 520 g of the N‐Boc‐ tert ‐leucine‐benzylester was resolved on the amylose‐based phase Chiralpak AD with a mixture of heptane/2‐propanol as the mobile phase. In both instances the corresponding enantiomers were obtained in high yield and high optical purity. Chirality 14:313–317, 2002. © 2002 Wiley‐Liss, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/chir.10042 |
| الاتاحة: | http://dx.doi.org/10.1002/chir.10042 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchir.10042 https://onlinelibrary.wiley.com/doi/pdf/10.1002/chir.10042 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.20D173E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/chir.10042 |
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