Academic Journal
أعرض في EDS

Dietary Nitrate Supplementation Does Not Alter Exercise Efficiency at High Altitude – Further Results From the Xtreme Alps Study

التفاصيل البيبلوغرافية
العنوان: Dietary Nitrate Supplementation Does Not Alter Exercise Efficiency at High Altitude – Further Results From the Xtreme Alps Study
المؤلفون: Philip J. Hennis, Andrew F. Cumpstey, Alasdair F. O’Doherty, Bernadette O. Fernandez, Edward T. Gilbert-Kawai, Kay Mitchell, Helen Moyses, Alexandra Cobb, Paula Meale, Helmut Pöhnl, Monty G. Mythen, Michael P. W. Grocott, Denny Z. H. Levett, Daniel S. Martin, Martin Feelisch, The Xtreme Alps Research Group, Adam Booth, Adam Sheperdigian, Alasdair O’Doherty, Alex Salam, Andrew Cumpstey, Bernadette Fernandez, Damian Mole, Daniel Grant, Daniel Martin, Denny Levett, Edith Kortekaas, Edward Gilbert, Fabio Rigat, Fiona Shrubb, Heng Yow, James Farrant, Jildou van der Kaaij, Jim Milledge, Jo Simpson, Laura Jackson, Liesl Wandrag, Lindsay Bisiker, Mark Edsell, Maryam Khosravi, Matt Sanborn, Michael Grocott, Michael Mythen, Nick Talbot, Oliver Burdall, Oliver Firth, Oliver Moses, Phil Hennis, Savini Wijesingha, Steve Dauncey, Tom Adams, Tom Woolley, Wilby Williamson, Will Jenner, Zeyn Mahomed
المصدر: Frontiers in Physiology, Vol 13 (2022)
بيانات النشر: Frontiers Media S.A.
سنة النشر: 2022
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: exercise, high altitude, hypoxia, nitric oxide, beetroot, nitrite, Physiology, QP1-981
الوصف: IntroductionNitrate supplementation in the form of beetroot juice (BRJ) ingestion has been shown to improve exercise tolerance during acute hypoxia, but its effect on exercise physiology remains unstudied during sustained terrestrial high altitude exposure. We hypothesized that performing exercise at high altitude would lower circulating nitrate and nitrite levels and that BRJ ingestion would reverse this phenomenon while concomitantly improving key determinants of aerobic exercise performance.MethodsTwenty seven healthy volunteers (21 male) underwent a series of exercise tests at sea level (SL, London, 75 m) and again after 5–8 days at high altitude (HA, Capanna Regina Margherita or “Margherita Hut,” 4,559 m). Using a double-blind protocol, participants were randomized to consume a beetroot/fruit juice beverage (three doses per day) with high levels of nitrate (∼0.18 mmol/kg/day) or a nitrate-depleted placebo (∼11.5 μmoles/kg/day) control drink, from 3 days prior to the exercise trials until completion. Submaximal constant work rate cycle tests were performed to determine exercise efficiency and a maximal incremental ramp exercise test was undertaken to measure aerobic capacity, using breath-by-breath pulmonary gas exchange measurements throughout. Concentrations of nitrate, nitrite and nitrosation products were quantified in plasma samples collected at 5 timepoints during the constant work rate tests. Linear mixed modeling was used to analyze data.ResultsAt both SL and HA, plasma nitrate concentrations were elevated in the nitrate supplementation group compared to placebo (P < 0.001) but did not change throughout increasing exercise work rate. Delta exercise efficiency was not altered by altitude exposure (P = 0.072) or nitrate supplementation (P = 0.836). V̇O2peak decreased by 24% at high altitude (P < 0.001) and was lower in the nitrate-supplemented group at both sea level and high altitude compared to placebo (P = 0.041). Dietary nitrate supplementation did not alter other peak exercise variables or ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1664-042X
Relation: https://www.frontiersin.org/articles/10.3389/fphys.2022.827235/full; https://doaj.org/toc/1664-042X; https://doaj.org/article/5874770ad0244740b9422554efa5fad6
DOI: 10.3389/fphys.2022.827235
الاتاحة: https://doi.org/10.3389/fphys.2022.827235
https://doaj.org/article/5874770ad0244740b9422554efa5fad6
رقم الانضمام: edsbas.2093EC17
قاعدة البيانات: BASE
الوصف
تدمد:1664042X
DOI:10.3389/fphys.2022.827235