التفاصيل البيبلوغرافية
| العنوان: |
Host Cell Entry and Neutralization Sensitivity of SARS-CoV-2 Lineages B.1.620 and R.1 |
| المؤلفون: |
Anzhalika Sidarovich, Nadine Krüger, Cheila Rocha, Luise Graichen, Amy Kempf, Inga Nehlmeier, Martin Lier, Anne Cossmann, Metodi V. Stankov, Sebastian R. Schulz, Georg M. N. Behrens, Hans-Martin Jäck, Stefan Pöhlmann, Markus Hoffmann |
| المصدر: |
Viruses; Volume 14; Issue 11; Pages: 2475 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
SARS-CoV-2, spike protein, B.1.620, R.1, cell entry, neutralization, antibody evasion, ACE2 binding |
| جغرافية الموضوع: |
agris |
| الوصف: |
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitates viral entry into host cells and is the key target for neutralizing antibodies. The SARS-CoV-2 lineage B.1.620 carries fifteen mutations in the S protein and is spread in Africa, the US and Europe, while lineage R.1 harbors four mutations in S and infections were observed in several countries, particularly Japan and the US. However, the impact of the mutations in B.1.620 and R.1 S proteins on antibody-mediated neutralization and host cell entry are largely unknown. Here, we report that these mutations are compatible with robust ACE2 binding and entry into cell lines, and they markedly reduce neutralization by vaccine-induced antibodies. Our results reveal evasion of neutralizing antibodies by B.1.620 and R.1, which might have contributed to the spread of these lineages. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
SARS-CoV-2 and COVID-19; https://dx.doi.org/10.3390/v14112475 |
| DOI: |
10.3390/v14112475 |
| الاتاحة: |
https://doi.org/10.3390/v14112475 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.208ABEA4 |
| قاعدة البيانات: |
BASE |