Academic Journal
A sequence highly similar to PNG is located on chromosome 22q12 in intron 15 of the LIMK‐2 gene
| العنوان: | A sequence highly similar to PNG is located on chromosome 22q12 in intron 15 of the LIMK‐2 gene |
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| المؤلفون: | Carson, Darek Kedra Emma, Weber, Günther, Lagercrantz, Jacob |
| المصدر: | IUBMB Life ; volume 44, issue 3, page 589-594 ; ISSN 1521-6543 1521-6551 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1998 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | In this report we describe a sequence (PNG22) highly similar to the Phospholipase C β3 Neighboring Gene (PNG). We also report that PNG22 is located in the q12 region on chromosome 22 between markers D22S1144 and D22S280. This finding explains that PNG probes cross hybridize to sequences on chromosome 22. Fine mapping using our sequence data and the complete sequence of a PAC clone (DJ515N1), located in this region, determined that PNG22 is located in intron 15 of the LIMK‐2 gene. PNG22 is 93% homologous to PNG, however it do not have the introns described for the PNG gene, instead matching the cDNA sequence. This leads us to suggest that PNG22 probably represents a PNG pseudogene. In this report we also list the exon intron borders and the genomic structure of LIMK‐2 and place it on the Sanger Center chromosome 22 Physical map. It also explains the finding that PNG probes cross hybridize to sequences on chromosome 22. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1080/15216549800201622 |
| الاتاحة: | http://dx.doi.org/10.1080/15216549800201622 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1080%2F15216549800201622 https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/15216549800201622 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.20892798 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/15216549800201622 |
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