Academic Journal
Characterization and Bio-Evaluation of the Synergistic Effect of Simvastatin and Folic Acid as Wound Dressings on the Healing Process
| العنوان: | Characterization and Bio-Evaluation of the Synergistic Effect of Simvastatin and Folic Acid as Wound Dressings on the Healing Process |
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| المؤلفون: | Mahmoud A. Hashem, Badriyah S. Alotaibi, Mahmoud M. A. Elsayed, Manal E. Alosaimi, Amal K. Hussein, Maram H. Abduljabbar, Kyung-Tae Lee, Hamdy Abdelkader, Mohamed A. El-Mokhtar, Ahmed H.E. Hassan, Amany A. Abdel-Rheem, Amany Belal, Mohammed S. Saddik |
| المصدر: | Pharmaceutics, Vol 15, Iss 2423, p 2423 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | simvastatin, polymeric films, wound healing, gene expression, histopathological examination, Pharmacy and materia medica, RS1-441 |
| الوصف: | Wound healing is a significant healthcare problem that decreases the patient’s quality of life. Hence, several agents and approaches have been widely used to help accelerate wound healing. The challenge is to search for a topical delivery system that could supply long-acting effects, accurate doses, and rapid healing activity. Topical forms of simvastatin (SMV) are beneficial in wound care. This study aimed to develop a novel topical chitosan-based platform of SMV with folic acid (FA) for wound healing. Moreover, the synergistic effect of combinations was determined in an excisional wound model in rats. The prepared SMV-FA-loaded films (SMV-FAPFs) were examined for their physicochemical characterizations and morphology. Box-Behnken Design and response surface methodology were used to evaluate the tensile strength and release characteristics of the prepared SMV-FAPFs. Additionally, Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), X-ray diffraction pattern (XRD), and animal studies were also investigated. The developed SMV-FAPFs showed a contraction of up to 80% decrease in the wound size after ten days. The results of the quantitative real-time polymerase chain reaction (RT-PCR) analysis demonstrated a significant upregulation of dermal collagen type I (CoTI) expression and downregulation of the inflammatory JAK3 expression in wounds treated with SMV-FAPFs when compared to control samples and individual drug treatments. In summary, it can be concluded that the utilization of SMV-FAPFs holds great potential for facilitating efficient and expeditious wound healing, hence presenting a feasible substitute for conventional topical administration methods. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1999-4923 |
| Relation: | https://www.mdpi.com/1999-4923/15/10/2423; https://doaj.org/toc/1999-4923; https://doaj.org/article/2d0bdabb9c69401a9856bdb64f152975 |
| DOI: | 10.3390/pharmaceutics15102423 |
| الاتاحة: | https://doi.org/10.3390/pharmaceutics15102423 https://doaj.org/article/2d0bdabb9c69401a9856bdb64f152975 |
| رقم الانضمام: | edsbas.20835073 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19994923 |
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| DOI: | 10.3390/pharmaceutics15102423 |