Academic Journal
Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents.
| العنوان: | Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents. |
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| المؤلفون: | Chidambaran, Vidya, Venkatasubramanian, Raja, Sadhasivam, Senthilkumar, Esslinger, Hope, Cox, Shareen, Diepstraten, Jeroen, Fukuda, Tsuyoshi, Inge, Thomas, Knibbe, Catherijne A J, Vinks, Alexander A |
| المصدر: | Paediatr Anaesth ; ISSN:1460-9592 ; Volume:25 ; Issue:9 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | anesthetics i.v., bariatric, bispectral index, obese, pediatric, pharmacodynamics, pharmacokinetics, propofol, simulation |
| الوصف: | Optimal dosing of propofol to maintain appropriate anesthetic depth is challenging in severely obese (SO) adolescents. We previously reported that total body weight (TBW) is predictive of propofol clearance. This study was aimed at characterizing pharmacokinetics (PK) and pharmacodynamics (PD) of propofol in SO adolescents, using bispectral index (BIS), and toward developing PK/PD model-based dosing guidelines. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.1111/pan.12684; https://pubmed.ncbi.nlm.nih.gov/25975390; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516654/ |
| DOI: | 10.1111/pan.12684 |
| الاتاحة: | https://doi.org/10.1111/pan.12684 https://pubmed.ncbi.nlm.nih.gov/25975390 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516654/ |
| Rights: | © 2015 John Wiley & Sons Ltd. |
| رقم الانضمام: | edsbas.20793D24 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/pan.12684 |
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