التفاصيل البيبلوغرافية
| العنوان: |
Investigation of the Vitamin D Receptor Polymorphisms in Acromegaly Patients |
| المؤلفون: |
Muzaffer Ilhan, Bahar Toptas-Hekimoglu, Ilhan Yaylim, Seda Turgut, Saime Turan, Ozcan Karaman, Ertugrul Tasan |
| بيانات النشر: |
BioMed Research International |
| سنة النشر: |
2015 |
| المجموعة: |
Hindawi Publishing Corporation |
| مصطلحات موضوعية: |
Genetics |
| الوصف: |
Objective. The genetic structural alterations in the majority of somatotroph adenomas are not clarified and the search for novel candidate genes is still a challenge. We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms and acromegaly. Design, Patients, and Methods. 52 acromegaly patients (mean age 45.7±1.9 years) and 83 controls (mean age 43.1±2.6 years) were recruited to the study. VDR polymorphism was determined by polymerase chain reaction-based restriction fragment length polymorphism methods. Results. The distribution of VDR genotypes showed a significant difference in the frequencies of VDR FokI genotypes between patients and controls (P=0.034). VDR FokI ff genotype was significantly decreased in acromegaly patients (P=0.035) and carriers of FokI Ff genotype had a 1.5-fold increased risk for acromegaly (OR: 1.5, 95% CI: 1.07–2.1; P=0.020). IGF1 levels after treatment were significantly higher in patients carrying the Ff genotype compared to carrying ff genotype (P=0.0049). 25(OH)D3 levels were significantly lower in acromegaly patients (P<0.001). Conclusions. Our study suggests that VDR FokI genotypes might affect the development of acromegaly and VDR polymorphisms may play a role in the course of acromegaly as a consequence of altering hormonal status. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
https://doi.org/10.1155/2015/625981 |
| DOI: |
10.1155/2015/625981 |
| الاتاحة: |
https://doi.org/10.1155/2015/625981 |
| Rights: |
Copyright © 2015 Muzaffer Ilhan et al. |
| رقم الانضمام: |
edsbas.204B939B |
| قاعدة البيانات: |
BASE |