Academic Journal
The Wnt Pathway in Mood Disorders
| العنوان: | The Wnt Pathway in Mood Disorders |
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| المؤلفون: | SANI, Gabriele, NAPOLETANO, FLAVIA, FORTE, ALBERTO, KOTZALIDIS, GIORGIO, PANACCIONE, ISABELLA, SIMONETTI, ALESSIO, GIRARDI, NICOLETTA, SERRA, GIULIA, RAPINESI, CHIARA, DEL CASALE, ANTONIO, NICOLETTI, Ferdinando, GIRARDI, Paolo, G. M. Porfiri, Matteo Caloro, C. L. Telesforo, Silvia Romano, Giovanni Manfredi, Valeria Savoja, S. M. Tamorri, KOUKOPOULOS, ALEXIA, Daniele Serata |
| المساهمون: | Sani, Gabriele, Napoletano, Flavia, Forte, Alberto, Kotzalidis, Giorgio, Panaccione, Isabella, G. M., Porfiri, Simonetti, Alessio, Matteo, Caloro, Girardi, Nicoletta, C. L., Telesforo, Serra, Giulia, Silvia, Romano, Giovanni, Manfredi, Valeria, Savoja, S. M., Tamorri, Koukopoulos, Alexia, Daniele, Serata, Rapinesi, Chiara, DEL CASALE, Antonio, Nicoletti, Ferdinando, Girardi, Paolo |
| بيانات النشر: | BENTHAM SCIENCE PUBL LTD |
| سنة النشر: | 2012 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | antidepressant drug, antipsychotic drug, bipolar disorder, major depression, mood disorder, mood stabilising agent, wingless (wnt) signalling |
| الوصف: | Objectives: To review the evidence of the involvement of the Wnt signalling pathway in mood disorders and in the action of drugs used to treat these disorders. Methods: We performed a careful PubMed search using as keywords all possible terms relevant to the Wnt pathway and crossing them with each of four areas, i.e., developmental effects, behavioural effects, mood disorders, and drugs used in their treatment. Papers were selected on the basis of their content and their data used for discussion. Results: Neurodevelopmental and behavioural data point to the possibility of involvement of the Wnt pathway in the pathophysiology of mood disorders. Clinical and post-mortem data are not sufficient to corroborate a definite role for Wnt alterations in any mood disorder. Combining genetic and pharmacological data, we may state that glycogen synthase kinase is the key molecule in bipolar disorder, as it is connected with many other signalling pathways that were shown to be involved in mood disorders, while Wnt molecules in the hippocampus appear to be mainly involved in depressive disorders. Conclusions: Altered Wnt signalling may play a role in the pathophysiology of mood disorders, although not a central one. It is premature to draw conclusions regarding the possible usefulness of Wnt manipulations in the treatment of mood disorders. © 2012 Bentham Science Publishers. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/23449817; info:eu-repo/semantics/altIdentifier/wos/WOS:000309491600006; volume:10; issue:3; firstpage:239; lastpage:253; numberofpages:15; journal:CURRENT NEUROPHARMACOLOGY; http://hdl.handle.net/11573/495410; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84867564968 |
| DOI: | 10.2174/157015912803217279 |
| الاتاحة: | http://hdl.handle.net/11573/495410 https://doi.org/10.2174/157015912803217279 |
| رقم الانضمام: | edsbas.20476DC7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/157015912803217279 |
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