Academic Journal
Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning
| العنوان: | Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning |
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| المؤلفون: | Hirschhäuser, Christine, Lissoni, Alessio, Görge, Philipp Maximilian, Lampe, Paul D., Heger, Jacqueline, Schlüter, Klaus-Dieter, Leybaert, Luc, Schulz, Rainer, Boengler, Kerstin |
| المصدر: | http://lobid.org/resources/99370671625606441#!, 116(1):21. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Mitochondria, Connexin, Phosphorylation [MeSH], Original Contribution, Myocardial Infarction/pathology [MeSH], Heart/enzymology [MeSH], Myocardial Reperfusion Injury/genetics [MeSH], Ischemic preconditioning, Ischemia/reperfusion, Phosphorylation, Myocardial Infarction/enzymology [MeSH], Disease Models, Animal [MeSH], Hemichannel, Myocardial Reperfusion Injury/pathology [MeSH], Heart/pathology [MeSH], Myocardial Infarction/prevention, Myocytes, Cardiac/enzymology [MeSH], Casein Kinase I/metabolism [MeSH], Myocardial Infarction/genetics [MeSH], Animals [MeSH], Myocardial [MeSH], Cardiac/pathology [MeSH], Heart/genetics [MeSH], Myocardial Reperfusion Injury/prevention, Mice, Mutant Strains [MeSH], Myocardial Reperfusion Injury/enzymology [MeSH], Connexin 43/genetics [MeSH] |
| الوصف: | Myocardial connexin 43 (Cx43) forms gap junctions and hemichannels, and is also present within subsarcolemmal mitochondria. The protein is phosphorylated by several kinases including mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and casein kinase 1 (CK1). A reduction in Cx43 content abrogates myocardial infarct size reduction by ischemic preconditioning (IPC). The present study characterizes the contribution of Cx43 phosphorylation towards mitochondrial function, hemichannel activity, and the cardioprotection by IPC in wild-type (WT) mice and in mice in which Cx43-phosphorylation sites targeted by above kinases are mutated to non-phosphorylatable residues (Cx43 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-9937-0-6716-4 9937-0-6716-2 |
| Relation: | https://repository.publisso.de/resource/frl:6450760; https://doi.org/10.1007/s00395-021-00861-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985055/ |
| DOI: | 10.1007/s00395-021-00861-z |
| الاتاحة: | https://repository.publisso.de/resource/frl:6450760 https://doi.org/10.1007/s00395-021-00861-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985055/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.2034DB92 |
| قاعدة البيانات: | BASE |
| ردمك: | 9789937067164 9937067162 |
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| DOI: | 10.1007/s00395-021-00861-z |